White matter architecture in a normal pediatric population: a diffusion tensor MRI study. Hum Brain Mapp 26: 139147. 22. Bunce D, Anstey KJ, Cherbuin N, Burns R, Christensen H, et al. 125-65-5 site Cognitive deficits are 871361-88-5 web associated with frontal and temporal lobe white matter lesions in middle-aged adults living within the neighborhood. PloS A single 5: e13567. 23. Nordahl CW, Ranganath C, Yonelinas AP, Decarli C, Fletcher E, et al. White matter changes compromise prefrontal cortex function in healthy elderly folks. J Cogn Neurosci 18: 418429. 24. Duncan J, Seltz RJ, Kolodny J, Bor D, Herzog H, et al. A neural basis for general intelligence. Am J Ophthalmol 130: 687. 25. Gray JR, Chabris CF, Braver TS Neural mechanisms of general fluid intelligence. Nat Neurosci 6: 316322. 26. Gerton BK, Brown TT, Meyer-Lindenberg A, Kohn P, Holt JL, et al. Shared and distinct neurophysiological components of the digits forward and backward tasks as revealed by functional neuroimaging. Neuropsychologia 42: 17811787. 27. Shin J, Choi S, Lee JE, Lee HS, Sohn YH, et al. Subcortical white matter hyperintensities within the cholinergic pathways of Parkinson’s illness sufferers based on cognitive status. J Neurol Neurosurg Psychiatry 83: 315321. 28. Gregoire J, Van der Linden M Effects of age on forward and backward digit spans. Aging Neuropsychol Cogn 4: 140149. 29. Muangpaisan W, Intalapaporn S, Assantachai P Digit span and verbal fluency tests in sufferers with mild cognitive impairment and normal subjects in Thai-community. J Med Assoc Thai 93: 224230. 30. La Rue A, Jarvik 23148522 LF Cognitive function and prediction of dementia in old age. Int J Aging Hum Dev 25: 7989. 31. Ahn HJ, Search engine marketing SW, Chin J, Suh MK, Lee BH, et al. The cortical neuroanatomy of neuropsychological deficits in mild cognitive impairment and Alzheimer’s disease: a surface-based morphometric evaluation. Neuropsychologia 49: 39313945. 32. Thomason ME, Dougherty RF, Colich NL, Perry LM, Rykhlevskaia EI, et al. COMT genotype affects prefrontal white matter pathways in youngsters and adolescents. Neuroimage 53: 926934. 33. Liu B, Li J, Yu C, Li Y, Liu Y, et al. Haplotypes of catechol-Omethyltransferase modulate intelligence-related brain white matter integrity. Neuroimage 50: 243249. 34. Xu H, Yang HJ, McConomy B, Browning R, Li XM Behavioral and neurobiological changes in C57BL/6 mouse exposed to cuprizone: effects of antipsychotics. Front Behav Neurosci 4: 8. 35. Xu H, Yang HJ, Zhang Y, Clough R, Browning R, et al. Behavioral and neurobiological modifications in C57BL/6 mice exposed to cuprizone. Behav Neurosci 123: 418429. 36. Berman S, O’Neill J, Fears S, Bartzokis G, London ED Abuse of amphetamines and structural abnormalities in the brain. Ann N Y Acad Sci 1141: 195220. 37. Wang Y, Berndt TJ, Gross JM, Peterson MA, So MJ, et al. Impact of inhibition of MAO and COMT on intrarenal dopamine and serotonin and on renal function. Am J Physiol Regul Integr Comp Physiol 280: R248254. 38. Pugh KG, Lipsitz LA The microvascular frontal-subcortical syndrome of aging. Neurobiol Aging 23: 421431. 39. Krimer LS, Muly EC 3rd, Williams GV, Goldman-Rakic PS Dopaminergic regulation of cerebral cortical microcirculation. Nat Neurosci 1: 286289. 40. Tomimoto H, Ihara M, Wakita H, Ohtani R, Lin JX, et al. Chronic cerebral hypoperfusion induces white matter lesions and loss of oligodendroglia with DNA fragmentation in the rat. Acta Neuropathol 106: 527534. 41. Fernstrom JD Can nutrient supplements modify brain function Am J Clin Nutr 71: 1669S167.White matter architecture inside a standard pediatric population: a diffusion tensor MRI study. Hum Brain Mapp 26: 139147. 22. Bunce D, Anstey KJ, Cherbuin N, Burns R, Christensen H, et al. Cognitive deficits are connected with frontal and temporal lobe white matter lesions in middle-aged adults living within the neighborhood. PloS One particular five: e13567. 23. Nordahl CW, Ranganath C, Yonelinas AP, Decarli C, Fletcher E, et al. White matter adjustments compromise prefrontal cortex function in wholesome elderly people. J Cogn Neurosci 18: 418429. 24. Duncan J, Seltz RJ, Kolodny J, Bor D, Herzog H, et al. A neural basis for basic intelligence. Am J Ophthalmol 130: 687. 25. Gray JR, Chabris CF, Braver TS Neural mechanisms of general fluid intelligence. Nat Neurosci 6: 316322. 26. Gerton BK, Brown TT, Meyer-Lindenberg A, Kohn P, Holt JL, et al. Shared and distinct neurophysiological elements from the digits forward and backward tasks as revealed by functional neuroimaging. Neuropsychologia 42: 17811787. 27. Shin J, Choi S, Lee JE, Lee HS, Sohn YH, et al. Subcortical white matter hyperintensities inside the cholinergic pathways of Parkinson’s disease individuals as outlined by cognitive status. J Neurol Neurosurg Psychiatry 83: 315321. 28. Gregoire J, Van der Linden M Effects of age on forward and backward digit spans. Aging Neuropsychol Cogn four: 140149. 29. Muangpaisan W, Intalapaporn S, Assantachai P Digit span and verbal fluency tests in individuals with mild cognitive impairment and regular subjects in Thai-community. J Med Assoc Thai 93: 224230. 30. La Rue A, Jarvik 23148522 LF Cognitive function and prediction of dementia in old age. Int J Aging Hum Dev 25: 7989. 31. Ahn HJ, Search engine optimisation SW, Chin J, Suh MK, Lee BH, et al. The cortical neuroanatomy of neuropsychological deficits in mild cognitive impairment and Alzheimer’s illness: a surface-based morphometric analysis. Neuropsychologia 49: 39313945. 32. Thomason ME, Dougherty RF, Colich NL, Perry LM, Rykhlevskaia EI, et al. COMT genotype impacts prefrontal white matter pathways in children and adolescents. Neuroimage 53: 926934. 33. Liu B, Li J, Yu C, Li Y, Liu Y, et al. Haplotypes of catechol-Omethyltransferase modulate intelligence-related brain white matter integrity. Neuroimage 50: 243249. 34. Xu H, Yang HJ, McConomy B, Browning R, Li XM Behavioral and neurobiological changes in C57BL/6 mouse exposed to cuprizone: effects of antipsychotics. Front Behav Neurosci 4: 8. 35. Xu H, Yang HJ, Zhang Y, Clough R, Browning R, et al. Behavioral and neurobiological adjustments in C57BL/6 mice exposed to cuprizone. Behav Neurosci 123: 418429. 36. Berman S, O’Neill J, Fears S, Bartzokis G, London ED Abuse of amphetamines and structural abnormalities within the brain. Ann N Y Acad Sci 1141: 195220. 37. Wang Y, Berndt TJ, Gross JM, Peterson MA, So MJ, et al. Effect of inhibition of MAO and COMT on intrarenal dopamine and serotonin and on renal function. Am J Physiol Regul Integr Comp Physiol 280: R248254. 38. Pugh KG, Lipsitz LA The microvascular frontal-subcortical syndrome of aging. Neurobiol Aging 23: 421431. 39. Krimer LS, Muly EC 3rd, Williams GV, Goldman-Rakic PS Dopaminergic regulation of cerebral cortical microcirculation. Nat Neurosci 1: 286289. 40. Tomimoto H, Ihara M, Wakita H, Ohtani R, Lin JX, et al. Chronic cerebral hypoperfusion induces white matter lesions and loss of oligodendroglia with DNA fragmentation in the rat. Acta Neuropathol 106: 527534. 41. Fernstrom JD Can nutrient supplements modify brain function Am J Clin Nutr 71: 1669S167.