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In contrast to the situation in the wild type cells, LP BER was not stimulated in WRN KD cells after sodium butyrate treatment

mglur mglur April 28, 2017 0 Comments

1360 did not localize to LDs while another that lacks 1319 did. A short GFP-tagged fragment containing the hydrophobic domain was able to localize to LDs. Bars, 5 mm. PNPLA…

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labeled with 0.5 mCi/ml sodium acetate for 1 h. Lower panels: Western analysis of acetylated samples with an anti-WRN antibody

mglur mglur April 27, 2017 0 Comments

ere routinely dehydrated in ethanol, equilibrated in xylene and embedded in paraffin according to standard histological procedures. Sections of 35 mm were stained with haematoxylin and eosin and blindly evaluated…

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The influence of AS-miR-24 on p16 translation was further tested by employing a heterologous reporter system that studies the expression of d2EGFP

mglur mglur April 27, 2017 0 Comments

ed in 131 primary pediatric AML samples with also high expression in t-positive patients. Another study investigated four miRNAs, miR-29a, -155, -196a, and -196b, in 82 pediatric AML samples and…

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The distribution of p16 mRNA was compared between Y and S cells. Unexpectedly, despite the low p16 protein levels in Y cells

mglur mglur April 26, 2017 0 Comments

r attention in future work. For example, Ras may have at least one more effector other than Raf such as PI3K . An adaptor protein, Grb2, one of the key…

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It is known that HESC do express low baseline levels of lineage-specific markers so when differentiation is triggered by EB formation

mglur mglur April 26, 2017 0 Comments

018 0.019 0.019 effluent of neonates with BPD may occur even in the absence of bacterial colonization. The transcriptional activators, NFkB and STAT3, were predicted to be activated by IPA…

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MC631 and TRA-1-60 antibodies were prepared as supernatants of the hybridomas grown in our laboratory as previously described

mglur mglur April 25, 2017 0 Comments

case and exonuclease activities in vitro and in vivo. The level of WRN acetylation increases in cells exposed to methyl methanesulfonate, and long-patch BER activity increases in wild type but…

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we had already lost two-thirds of our SirT1-null mice by the end of this experiment and CR had no obvious beneficial effect on lifespan of these mice

mglur mglur April 25, 2017 0 Comments

e. In the HSF1 promoter, the CGGBP1 binding site could not be site-specifically mutated due to extremely high GC richness and repetitive nature of this region. Instead, we deleted a…

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The dependence on NAD+ as a cofactor for catalysis is thought to link SirT1 activity to the energetic state of the cell

mglur mglur April 24, 2017 0 Comments

ng Measurement Left Ventricular Mass Ejection Fraction Fractional Shortening Normal Diet 15267 7561 4361 High-Fat Diet 13267 7462 4262 Data was obtained from M-mode echocardiographic images taken in parasternal short…

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The two extra residues in the typical 26-residue-long CC-LRRs compared to the 24-residue-long GALA- and GL-LRRs

mglur mglur April 24, 2017 0 Comments

in activity was not affected by Bt-maize either in whole fish or intestinal tract sections during the trial. Amylase activity in PI was significantly increased due to Bt-maize feeding on…

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The fourth aspect of our work relates to the observation that binding between HLA-DRa2 and TIRC7 is functional in T cells HLA-DR Alpha 2 and APC

mglur mglur April 21, 2017 0 Comments

anscriptional repression. This and different knockout phenotypes of NFI genes indicate the 6-Methoxy-2-benzoxazolinone biological activity existence of mechanisms specific for each member. Differential interactions with other proteins, conferred by different…

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PDZ domain containing ring finger 3

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