Product Name :
SB-705498
Description:
SB-705498 is an orally bioavailable, competitive antagonist of the capsaicin-mediated activation of TRPV1 receptors (pKis = 7.6, 7.5, and 7.3 for human, rat, and guinea pig, respectively). SB-705498 inhibits the capsaicin-, acid-, and heat-mediated activation of the receptor. SB-705498 was shown to be a potent competitive antagonist of the capsaicin-mediated activation of the human TRPV1 receptor (pK(i) = 7.6) with activity at rat (pK(i) = 7.5) and guinea pig (pK(i) = 7.3) orthologs.
CAS:
501951-42-4
Molecular Weight:
429.23
Formula:
C17H16BrF3N4O
Chemical Name:
1-(2-bromophenyl)-3-[(3R)-1-[5-(trifluoromethyl)pyridin-2-yl]pyrrolidin-3-yl]urea
Smiles :
O=C(NC1=CC=CC=C1Br)N[C@H]1CN(CC1)C1=CC=C(C=N1)C(F)(F)F
InChiKey:
JYILLRHXRVTRSH-GFCCVEGCSA-N
InChi :
InChI=1S/C17H16BrF3N4O/c18-13-3-1-2-4-14(13)24-16(26)23-12-7-8-25(10-12)15-6-5-11(9-22-15)17(19,20)21/h1-6,9,12H,7-8,10H2,(H2,23,24,26)/t12-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
SB-705498 is an orally bioavailable, competitive antagonist of the capsaicin-mediated activation of TRPV1 receptors (pKis = 7.{{Mirikizumab} medchemexpress|{Mirikizumab} Interleukin Related|{Mirikizumab} Protocol|{Mirikizumab} In stock|{Mirikizumab} manufacturer|{Mirikizumab} Epigenetic Reader Domain} 6, 7.{{Telithromycin} MedChemExpress|{Telithromycin} Bacterial|{Telithromycin} Protocol|{Telithromycin} In Vitro|{Telithromycin} manufacturer|{Telithromycin} Autophagy} 5, and 7.PMID:23865629 3 for human, rat, and guinea pig, respectively). SB-705498 inhibits the capsaicin-, acid-, and heat-mediated activation of the receptor. SB-705498 was shown to be a potent competitive antagonist of the capsaicin-mediated activation of the human TRPV1 receptor (pK(i) = 7.6) with activity at rat (pK(i) = 7.5) and guinea pig (pK(i) = 7.3) orthologs.|Product information|CAS Number: 501951-42-4|Molecular Weight: 429.23|Formula: C17H16BrF3N4O|Chemical Name: 1-(2-bromophenyl)-3-[(3R)-1-[5-(trifluoromethyl)pyridin-2-yl]pyrrolidin-3-yl]urea|Smiles: O=C(NC1=CC=CC=C1Br)N[C@H]1CN(CC1)C1=CC=C(C=N1)C(F)(F)F|InChiKey: JYILLRHXRVTRSH-GFCCVEGCSA-N|InChi: InChI=1S/C17H16BrF3N4O/c18-13-3-1-2-4-14(13)24-16(26)23-12-7-8-25(10-12)15-6-5-11(9-22-15)17(19,20)21/h1-6,9,12H,7-8,10H2,(H2,23,24,26)/t12-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|