Product Name :
PDD 00017273
Description:
PDD 00017273 is a potent inhibitor of Poly(ADP-ribose) Glycohydrolase (PARG), with an IC50 of 26 nM, and a KD of 1.45 nM.
CAS:
1945950-21-9
Molecular Weight:
514.62
Formula:
C23H26N6O4S2
Chemical Name:
1-[(1,3-dimethyl-1H-pyrazol-5-yl)methyl]-3-[(2-methyl-1,3-thiazol-5-yl)methyl]-N-(1-methylcyclopropyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide
Smiles :
CN1N=C(C)C=C1CN1C2=CC=C(C=C2C(=O)N(CC2=CN=C(C)S2)C1=O)S(=O)(=O)NC1(C)CC1
InChiKey:
IFWUBRBMMNTBRZ-UHFFFAOYSA-N
InChi :
InChI=1S/C23H26N6O4S2/c1-14-9-16(27(4)25-14)12-28-20-6-5-18(35(32,33)26-23(3)7-8-23)10-19(20)21(30)29(22(28)31)13-17-11-24-15(2)34-17/h5-6,9-11,26H,7-8,12-13H2,1-4H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Azadirachtin} MedChemExpress|{Azadirachtin} Anti-infection|{Azadirachtin} Purity & Documentation|{Azadirachtin} In Vitro|{Azadirachtin} supplier|{Azadirachtin} Cancer}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
PDD 00017273 is a potent inhibitor of Poly(ADP-ribose) Glycohydrolase (PARG), with an IC50 of 26 nM, and a KD of 1.45 nM.|Product information|CAS Number: 1945950-21-9|Molecular Weight: 514.62|Formula: C23H26N6O4S2|Chemical Name: 1-[(1,3-dimethyl-1H-pyrazol-5-yl)methyl]-3-[(2-methyl-1,3-thiazol-5-yl)methyl]-N-(1-methylcyclopropyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide|Smiles: CN1N=C(C)C=C1CN1C2=CC=C(C=C2C(=O)N(CC2=CN=C(C)S2)C1=O)S(=O)(=O)NC1(C)CC1|InChiKey: IFWUBRBMMNTBRZ-UHFFFAOYSA-N|InChi: InChI=1S/C23H26N6O4S2/c1-14-9-16(27(4)25-14)12-28-20-6-5-18(35(32,33)26-23(3)7-8-23)10-19(20)21(30)29(22(28)31)13-17-11-24-15(2)34-17/h5-6,9-11,26H,7-8,12-13H2,1-4H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 50 mg/mL (97.{{Chlorthalidone} site|{Chlorthalidone} Technical Information|{Chlorthalidone} References|{Chlorthalidone} supplier|{Chlorthalidone} Epigenetics} 16 mM; Need ultrasonic).PMID:23903683 |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PDD 00017273 is a potent inhibitor of PARG, with an IC50 of 26 nM, and a KD of 1.45 nM. PDD 00017273 (10 μM) does not inhibit five common Cytochrome P450 enzymes. PDD 00017273 (30 μM) modestly increasess phosphorylated H2AX (γH2AX) intensity, PDD 00017273 also decreases in NAD/H through PARG inhibition after DNA damage. PDD 00017273 suppresses the ZR-75-1 cells carring BRCA1 and BRCA2 wild type, and exhibits less potent activities against MDA-MB-436 cells carry the 5396 + 1G>A mutation in BRCA1. PDD 00017273 (0.3 μM) inhibits degradation of PAR polymers in MCF7 cells. PDD 00017273 (0.3 μM) also reduces the viability of BRCA1, BRCA2, PALB2, FAM175A, and BARD1 depleted cells. PDD 00017273 stalls replication forks and induces DNA damage that requires homologous recombination (HR) for repair.|Products are for research use only. Not for human use.|