Product Name :
IU1 — Proteasome USP14 Inhibitor
Description:
IU1 is a cell-permeable, reversible and selective inhibitor of human USP14 with an IC50 of 4.7 μM. It selectively stimulates ubiquitin-dependent protein degradation in vitro at 34 μM and in MEF cells at 50 μM. At 75 μM, IU1 reduces accumulation of oxidized proteins in HEK293 cells, alleviating cytotoxicity induced by oxidative stress. Usp14 inhibition accelerated the degradation of oxidized proteins and enhanced resistance to oxidative stress. Enhancement of proteasome activity through inhibition of Usp14 may offer a strategy to reduce the levels of aberrant proteins in cells under proteotoxic stress.
CAS:
314245-33-5
Molecular Weight:
300.37
Formula:
C18H21FN2O
Chemical Name:
1-(1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-2-(pyrrolidin-1-yl)ethanone
Smiles :
CC1=CC(C(=O)CN2CCCC2)=C(C)N1C1C=CC(F)=CC=1
InChiKey:
JUWDSDKJBMFLHE-UHFFFAOYSA-N
InChi :
InChI=1S/C18H21FN2O/c1-13-11-17(18(22)12-20-9-3-4-10-20)14(2)21(13)16-7-5-15(19)6-8-16/h5-8,11H,3-4,9-10,12H2,1-2H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
IU1 is a cell-permeable, reversible and selective inhibitor of human USP14 with an IC50 of 4.7 μM. It selectively stimulates ubiquitin-dependent protein degradation in vitro at 34 μM and in MEF cells at 50 μM. At 75 μM, IU1 reduces accumulation of oxidized proteins in HEK293 cells, alleviating cytotoxicity induced by oxidative stress. Usp14 inhibition accelerated the degradation of oxidized proteins and enhanced resistance to oxidative stress. Enhancement of proteasome activity through inhibition of Usp14 may offer a strategy to reduce the levels of aberrant proteins in cells under proteotoxic stress.|Product information|CAS Number: 314245-33-5|Molecular Weight: 300.{{Sotrovimab} MedChemExpress|{Sotrovimab} Anti-infection|{Sotrovimab} Purity & Documentation|{Sotrovimab} In Vitro|{Sotrovimab} custom synthesis|{Sotrovimab} Autophagy} 37|Formula: C18H21FN2O|Chemical Name: 1-(1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-2-(pyrrolidin-1-yl)ethanone|Smiles: CC1=CC(C(=O)CN2CCCC2)=C(C)N1C1C=CC(F)=CC=1|InChiKey: JUWDSDKJBMFLHE-UHFFFAOYSA-N|InChi: InChI=1S/C18H21FN2O/c1-13-11-17(18(22)12-20-9-3-4-10-20)14(2)21(13)16-7-5-15(19)6-8-16/h5-8,11H,3-4,9-10,12H2,1-2H3|Technical Data|Appearance: Solid Power.{{Infigratinib} web|{Infigratinib} Apoptosis|{Infigratinib} Protocol|{Infigratinib} References|{Infigratinib} custom synthesis|{Infigratinib} Autophagy} |Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO up to 100 mM|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:23891445 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined.|HS Tariff Code: 382200|How to use|In Vitro:|IU1 was used at 10-75 µM final concentration in various in vitro assays.|References:|Byung-Hoon L, et al. Enhancement of Proteasome Activity by a Small-Molecule Inhibitor of Usp14. (2010) Nature, 467(7312), 179-184.Products are for research use only. Not for human use.|Documents||