Product Name :
CMLD012072
Description:
CMLD012072 is an amidino-rocaglates and is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. CMLD012072 can induce RNA clamping of eIF4A1 and eIF4A2 and possess potent anti-neoplastic activity.
CAS:
2368900-33-6
Molecular Weight:
556.61
Formula:
C32H32N2O7
Chemical Name:
methyl (1R,9R,10S,11R,12R)-14-cyclopropyl-12-hydroxy-3,5-dimethoxy-9-(4-methoxyphenyl)-10-phenyl-8-oxa-13,15-diazatetracyclo[7.6.0.0¹,¹².0²,⁷]pentadeca-2,4,6,14-tetraene-11-carboxylate
Smiles :
COC(=O)[C@@H]1[C@@H](C2C=CC=CC=2)[C@@]2(OC3=CC(=CC(OC)=C3[C@]32N=C(N[C@]31O)C1CC1)OC)C1C=CC(=CC=1)OC
InChiKey:
KAEUWSZLWVZGMK-GAFFYMCOSA-N
InChi :
InChI=1S/C32H32N2O7/c1-37-21-14-12-20(13-15-21)30-25(18-8-6-5-7-9-18)27(29(35)40-4)32(36)31(30,33-28(34-32)19-10-11-19)26-23(39-3)16-22(38-2)17-24(26)41-30/h5-9,12-17,19,25,27,36H,10-11H2,1-4H3,(H,33,34)/t25-,27+,30+,31-,32-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Sotorasib} site|{Sotorasib} Ras|{Sotorasib} Biological Activity|{Sotorasib} Description|{Sotorasib} custom synthesis|{Sotorasib} Epigenetics}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Mogamulizumab} web|{Mogamulizumab} Immunology/Inflammation|{Mogamulizumab} Protocol|{Mogamulizumab} Description|{Mogamulizumab} supplier|{Mogamulizumab} Cancer}
Additional information:
CMLD012072 is an amidino-rocaglates and is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor.PMID:24190482 CMLD012072 can induce RNA clamping of eIF4A1 and eIF4A2 and possess potent anti-neoplastic activity.|Product information|CAS Number: 2368900-33-6|Molecular Weight: 556.61|Formula: C32H32N2O7|Chemical Name: methyl (1R,9R,10S,11R,12R)-14-cyclopropyl-12-hydroxy-3,5-dimethoxy-9-(4-methoxyphenyl)-10-phenyl-8-oxa-13,15-diazatetracyclo[7.6.0.0¹,¹².0²,⁷]pentadeca-2,4,6,14-tetraene-11-carboxylate|Smiles: COC(=O)[C@@H]1[C@@H](C2C=CC=CC=2)[C@@]2(OC3=CC(=CC(OC)=C3[C@]32N=C(N[C@]31O)C1CC1)OC)C1C=CC(=CC=1)OC|InChiKey: KAEUWSZLWVZGMK-GAFFYMCOSA-N|InChi: InChI=1S/C32H32N2O7/c1-37-21-14-12-20(13-15-21)30-25(18-8-6-5-7-9-18)27(29(35)40-4)32(36)31(30,33-28(34-32)19-10-11-19)26-23(39-3)16-22(38-2)17-24(26)41-30/h5-9,12-17,19,25,27,36H,10-11H2,1-4H3,(H,33,34)/t25-,27+,30+,31-,32-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|