Product Name :
Kobe0065
Description:
Kobe0065 is a small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction. Kobe0065 binds to Ras-GTP, blocking interactions with Raf kinase. Kobe0065 inhibits anchorage-dependent and -independent growth, blocks MEK/ERK activity and induces apoptosis in H-rasG12V transformed NIH3T3 cells. Kobe0065 also inhibits tumor growth in SW480 colon cancer cell xenografts.
CAS:
436133-68-5
Molecular Weight:
449.79
Formula:
C15H11ClF3N5O4S
Chemical Name:
3-(3-chloro-4-methylphenyl)-1-{[2,6-dinitro-4-(trifluoromethyl)phenyl]amino}thiourea
Smiles :
CC1=CC=C(C=C1Cl)NC(=S)NNC1C(=CC(=CC=1[N+]([O-])=O)C(F)(F)F)[N+]([O-])=O
InChiKey:
KSJVAYBCXSURMQ-UHFFFAOYSA-N
InChi :
InChI=1S/C15H11ClF3N5O4S/c1-7-2-3-9(6-10(7)16)20-14(29)22-21-13-11(23(25)26)4-8(15(17,18)19)5-12(13)24(27)28/h2-6,21H,1H3,(H2,20,22,29)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Kobe0065 is a small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction. Kobe0065 binds to Ras-GTP, blocking interactions with Raf kinase. Kobe0065 inhibits anchorage-dependent and -independent growth, blocks MEK/ERK activity and induces apoptosis in H-rasG12V transformed NIH3T3 cells. Kobe0065 also inhibits tumor growth in SW480 colon cancer cell xenografts.|Product information|CAS Number: 436133-68-5|Molecular Weight: 449.79|Formula: C15H11ClF3N5O4S|Chemical Name: 3-(3-chloro-4-methylphenyl)-1-{[2,6-dinitro-4-(trifluoromethyl)phenyl]amino}thiourea|Smiles: CC1=CC=C(C=C1Cl)NC(=S)NNC1C(=CC(=CC=1[N+]([O-])=O)C(F)(F)F)[N+]([O-])=O|InChiKey: KSJVAYBCXSURMQ-UHFFFAOYSA-N|InChi: InChI=1S/C15H11ClF3N5O4S/c1-7-2-3-9(6-10(7)16)20-14(29)22-21-13-11(23(25)26)4-8(15(17,18)19)5-12(13)24(27)28/h2-6,21H,1H3,(H2,20,22,29)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{α-Linolenic acid} medchemexpress|{α-Linolenic acid} Akt|{α-Linolenic acid} Biological Activity|{α-Linolenic acid} Description|{α-Linolenic acid} supplier|{α-Linolenic acid} Epigenetic Reader Domain} |Shelf Life: ≥360 days if stored properly.{{Riluzole} medchemexpress|{Riluzole} Sodium Channel|{Riluzole} Purity & Documentation|{Riluzole} In Vivo|{Riluzole} supplier|{Riluzole} Cancer} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23892407 |Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|