Product Name :
YS-49 monohydrate
Description:
YS-49 is an anti-inflammatory agent and activator of PI3K/Akt signaling. YS-49 regulates angiotensin II-stimulated ROS production, JNK phosphorylation and vascular smooth muscle cell proliferation via the induction of heme oxygenase-1. YS 49 induced HO-1 protein production in a dose-and time-dependent manner in VSMCs. Treatment with YS 49 significantly and dose-dependently inhibited Ang II-induced VSMC proliferation, ROS production, and phosphorylation of JNK, but not P38 MAP kinase or ERK1/2. YS 49 has potential as a therapeutic strategy for the pathogenesis of Ang II-related vascular diseases such as hypertension and atherosclerosis, via the induction of HO-1 gene activity.
CAS:
Molecular Weight:
404.30
Formula:
C20H22BrNO3
Chemical Name:
1-[(naphthalen-1-yl)methyl]-1, 2, 3, 4-tetrahydroisoquinoline-6, 7-diol hydrate hydrobromide
Smiles :
O.{{Tebentafusp} web|{Tebentafusp} Apoptosis|{Tebentafusp} Protocol|{Tebentafusp} Data Sheet|{Tebentafusp} custom synthesis|{Tebentafusp} Epigenetic Reader Domain} Br.OC1=CC2CCNC(CC3=CC=CC4=CC=CC=C34)C=2C=C1O
InChiKey:
QHCUNMLYODPTIU-UHFFFAOYSA-N
InChi :
InChI=1S/C20H19NO2.BrH.H2O/c22-19-11-15-8-9-21-18(17(15)12-20(19)23)10-14-6-3-5-13-4-1-2-7-16(13)14;;/h1-7,11-12,18,21-23H,8-10H2;1H;1H2
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
YS-49 is an anti-inflammatory agent and activator of PI3K/Akt signaling. YS-49 regulates angiotensin II-stimulated ROS production, JNK phosphorylation and vascular smooth muscle cell proliferation via the induction of heme oxygenase-1. YS 49 induced HO-1 protein production in a dose-and time-dependent manner in VSMCs. Treatment with YS 49 significantly and dose-dependently inhibited Ang II-induced VSMC proliferation, ROS production, and phosphorylation of JNK, but not P38 MAP kinase or ERK1/2. YS 49 has potential as a therapeutic strategy for the pathogenesis of Ang II-related vascular diseases such as hypertension and atherosclerosis, via the induction of HO-1 gene activity.|Product information|Molecular Weight: 404.30|Formula: C20H22BrNO3|Synonym:|YS49 monohydrate|YS 49 monohydrate|Related CAS Number:|132836-42-1 (YS-49 HBr)|626252-74-2 (YS-49(S) HBr)|626252-73-1 (YS-49(R) HBr)|Chemical Name: 1-[(naphthalen-1-yl)methyl]-1, 2, 3, 4-tetrahydroisoquinoline-6, 7-diol hydrate hydrobromide|Smiles: O.{{Letermovir} site|{Letermovir} Anti-infection|{Letermovir} Technical Information|{Letermovir} Description|{Letermovir} supplier|{Letermovir} Epigenetics} Br.PMID:24957087 OC1=CC2CCNC(CC3=CC=CC4=CC=CC=C34)C=2C=C1O|InChiKey: QHCUNMLYODPTIU-UHFFFAOYSA-N|InChi: InChI=1S/C20H19NO2.BrH.H2O/c22-19-11-15-8-9-21-18(17(15)12-20(19)23)10-14-6-3-5-13-4-1-2-7-16(13)14;;/h1-7,11-12,18,21-23H,8-10H2;1H;1H2|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|YS-49 (1-100 μM; 18 hours; RAVSMC and RAW 264.7 cells) concentration-dependently inhibits the accumulation of nitrite in both RAVSMC and RAW 264.7 exposed to lipopolysaccharide (LPS) plus INF-γ, with IC50 values of 22 μM and 30 μM, respectively. YS-49 (10-100 μM; 18 hours; RAVSMC and RAW 264.7 cells) suppresses iNOS gene expression induced by LPS and/or cytokines in RAVSMC and RAW 264.7 cells at the transcriptional level.|In Vivo:|YS-49 (5 mg/kg; intraperitoneal injection; 8 hours; male Sprague Dawley rats) treatment significantly reduces serum NOx levels in LPS-treated rats, the NOx levels reduce from 86 μM to 34 μM.|References:|Sun JJ, et al. YS 49, 1-(alpha-naphtylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, regulates angiotensin II-stimulated ROS production, JNK phosphorylation and vascular smooth muscle cell proliferation via the induction of heme oxygenase-1. Life Sci. 2008 Mar 12;82(11-12):600-7.Kang YJ, et al. Prevention of the expression of inducible nitric oxide synthase by a novel positive inotropic agent, YS 49, in rat vascular smooth muscle and RAW 264.7 macrophages. Br J Pharmacol. 1999 Sep;128(2):357-64.Hsu YH, et al. RhoA-mediated inhibition of vascular endothelial cell mobility: positive feedback through reduced cytosolic p21 and p27. J Cell Physiol. 2014 Oct;229(10):1455-65.Products are for research use only. Not for human use.|