Product Name :
CCG-50014
Description:
CCG-50014 is the most potent against the regulator of G-protein signaling protein type 4 (RGS4) (IC50 =30 nM) and is >20-fold selective for RGS4 over other RGS proteins. CCG-50014 binds covalently to the RGS, forming an adduct on two cysteine residues located in an allosteric regulatory site. CCG50014, reduces nociceptive responses and enhances opioid-mediated analgesic effects in the mouse formalin test.
CAS:
883050-24-6
Molecular Weight:
316.35
Formula:
C16H13FN2O2S
Chemical Name:
4-[(4-fluorophenyl)methyl]-2-(4-methylphenyl)-1,2,4-thiadiazolidine-3,5-dione
Smiles :
CC1C=CC(=CC=1)N1SC(=O)N(CC2C=CC(F)=CC=2)C1=O
InChiKey:
QUIIIYITNGOFEI-UHFFFAOYSA-N
InChi :
InChI=1S/C16H13FN2O2S/c1-11-2-8-14(9-3-11)19-15(20)18(16(21)22-19)10-12-4-6-13(17)7-5-12/h2-9H,10H2,1H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
CCG-50014 is the most potent against the regulator of G-protein signaling protein type 4 (RGS4) (IC50 =30 nM) and is >20-fold selective for RGS4 over other RGS proteins. CCG-50014 binds covalently to the RGS, forming an adduct on two cysteine residues located in an allosteric regulatory site. CCG50014, reduces nociceptive responses and enhances opioid-mediated analgesic effects in the mouse formalin test.{{Olacaftor} MedChemExpress|{Olacaftor} CFTR|{Olacaftor} Biological Activity|{Olacaftor} Purity|{Olacaftor} supplier|{Olacaftor} Cancer} |Product information|CAS Number: 883050-24-6|Molecular Weight: 316.{{Raludotatug} web|{Raludotatug} Protocol|{Raludotatug} Purity|{Raludotatug} manufacturer|{Raludotatug} Autophagy} 35|Formula: C16H13FN2O2S|Chemical Name: 4-[(4-fluorophenyl)methyl]-2-(4-methylphenyl)-1,2,4-thiadiazolidine-3,5-dione|Smiles: CC1C=CC(=CC=1)N1SC(=O)N(CC2C=CC(F)=CC=2)C1=O|InChiKey: QUIIIYITNGOFEI-UHFFFAOYSA-N|InChi: InChI=1S/C16H13FN2O2S/c1-11-2-8-14(9-3-11)19-15(20)18(16(21)22-19)10-12-4-6-13(17)7-5-12/h2-9H,10H2,1H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 62.PMID:24182988 5 mg/mL (197.57 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|CCG50014 (10, 30, or 100 nM) attenuates the nociceptive responses during the late phase in a dose-dependent manner.|Products are for research use only. Not for human use.|