Product Name :
Oroxin A
Description:
Oroxin A is the major component of an ethanol-water Oroxylum indicum (L.) Kurz (Bignoniaceae) seed extract (OISE). Oroxin A acts as a partial PPARγ agonist that can activate PPARγ transcriptional activation. Oroxin A activates PPARγ by docking into the PPARγ protein ligand-binding domain. Oroxin A also exhibits an inhibitory activity against α-glucosidase and an antioxidant capacity. Oroxin A exerts anti-breast cancer effects by inducing ER stress-mediated senescence.
CAS:
57396-78-8
Molecular Weight:
432.38
Formula:
C21H20O10
Chemical Name:
5,6-dihydroxy-2-phenyl-7-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-4H-chromen-4-one
Smiles :
OC[C@H]1O[C@@H](OC2C=C3OC(=CC(=O)C3=C(O)C=2O)C2C=CC=CC=2)[C@H](O)[C@@H](O)[C@@H]1O
InChiKey:
IPQKDIRUZHOIOM-IAAKTDFRSA-N
InChi :
InChI=1S/C21H20O10/c22-8-14-17(25)19(27)20(28)21(31-14)30-13-7-12-15(18(26)16(13)24)10(23)6-11(29-12)9-4-2-1-3-5-9/h1-7,14,17,19-22,24-28H,8H2/t14-,17-,19+,20-,21-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Ethacrynic acid} web|{Ethacrynic acid} Immunology/Inflammation|{Ethacrynic acid} Technical Information|{Ethacrynic acid} In Vivo|{Ethacrynic acid} supplier|{Ethacrynic acid} Epigenetics}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Oroxin A is the major component of an ethanol-water Oroxylum indicum (L.) Kurz (Bignoniaceae) seed extract (OISE). Oroxin A acts as a partial PPARγ agonist that can activate PPARγ transcriptional activation. Oroxin A activates PPARγ by docking into the PPARγ protein ligand-binding domain. Oroxin A also exhibits an inhibitory activity against α-glucosidase and an antioxidant capacity. Oroxin A exerts anti-breast cancer effects by inducing ER stress-mediated senescence.|Product information|CAS Number: 57396-78-8|Molecular Weight: 432.38|Formula: C21H20O10|Chemical Name: 5,6-dihydroxy-2-phenyl-7-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-4H-chromen-4-one|Smiles: OC[C@H]1O[C@@H](OC2C=C3OC(=CC(=O)C3=C(O)C=2O)C2C=CC=CC=2)[C@H](O)[C@@H](O)[C@@H]1O|InChiKey: IPQKDIRUZHOIOM-IAAKTDFRSA-N|InChi: InChI=1S/C21H20O10/c22-8-14-17(25)19(27)20(28)21(31-14)30-13-7-12-15(18(26)16(13)24)10(23)6-11(29-12)9-4-2-1-3-5-9/h1-7,14,17,19-22,24-28H,8H2/t14-,17-,19+,20-,21-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 250 mg/mL (578.{{Trastuzumab} MedChemExpress|{Trastuzumab} Protein Tyrosine Kinase/RTK|{Trastuzumab} Biological Activity|{Trastuzumab} References|{Trastuzumab} custom synthesis|{Trastuzumab} Autophagy} 20 mM; Need ultrasonic).PMID:23489613 |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Oroxin A (0.5- 100 μM; 24 hours) significantly increases the PPARγ transcription level and exhibits the strongest activation with 50 μM in HEK-293t cells.|Products are for research use only. Not for human use.|