Product Name :
Anti-APP, Human antibody
Applications:
ELISA,Flow Cyt
Reactivity :
Human
Conjugate:
Unconjugated
Advantages :
High lot-to-lot consistencyIncreased sensitivity and higher affinityAnimal-free production
Description:
| Description: Anti-APP, Human antibody is designed for detecting human APP specifically. Based on ELISA and/or FCM, Anti-APP, Human antibody reacts with human APP specifically. | Immunogen: Recombinant human APP | Host: Alpaca pacous | Isotype: Human IgG1 | Conjugate: Unconjugated | Specificity: Human APP | Purity: Recombinant Expression and Affinity purified | Concentration: 1mg/ml | Formation: Liquid, 10mM PBS (pH 7.5), 0.05% sucrose, 0.1% trehalose, 0.01% proclin300, 50% Glycerol | Storage: Store at –20 °C, (Avoid freeze / thaw cycles) | Background:Amyloid Precursor Protein (APP) or Amyloid beta precursor protein functions as a cell surface kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1.{{1326852-06-5} medchemexpress|{1326852-06-5} Protocol|{1326852-06-5} In stock|{1326852-06-5} manufacturer} APP is important for neurite growth, neuronal adhesion and axonogenesis.{{1905409-39-3} site|{1905409-39-3} Purity & Documentation|{1905409-39-3} In stock|{1905409-39-3} custom synthesis} APP is a 100-140 kDa transmembrane glycoprotein that exists as several isoforms resulting from alternative splicing.PMID:26561703 Proteolytic cleavage of APP by beta- and gamma-secretases results in the generation of beta amyloid, which is the primary component of senile plaques. Senile plaques are one of the major histopathologic features of Alzheimer’s disease. Abnormal regulation and processing of APP also plays a role in Down’s syndrome, early onset familial Alzheimer’s disease, and cerebral hemorrhage.
Description2 :
Anti-APP, Human antibody is designed for detecting human APP specifically. Based on ELISA and/or FCM, Anti-APP, Human antibody reacts with human APP specifically.
Immunogen:
Recombinant human APP
Host :
Alpaca pacous
Isotype:
Human IgG1
Purity :
Recombinant Expression and Affinity purified
Buffer :
Storage :
Store at –20 °C, (Avoid freeze / thaw cycles)
Function:
ELISA: 1:4,000-1:10000Flow Cytometry：1:200-1:1000Dilution factors are presented in the form of a range because the optimal dilution is a function of many factors, such as antigen density, permeability, etc. The actual dilution used must be determined empirically.