Product Name :
Bruceine D
Description:
Bruceine D is a Notch inhibitor with anti-cancer activity and induces apoptosis in several human cancer cells. Bruceine D is an effective botanical insect antifeedant with outstanding systemic properties, causing potent pest growth inhibitory activity. Bruceine D has strong anthelmintic activity against D. intermedius with an EC50 value of 0.57 mg/L.
CAS:
21499-66-1
Molecular Weight:
410.42
Formula:
C20H26O9
Chemical Name:
(1R, 2R, 3R, 6R, 8S, 12S, 13S, 14R, 15R, 16S, 17R)-2, 3, 12, 15, 16-pentahydroxy-9, 13, 17-trimethyl-5, 18-dioxapentacyclo[12.5.0.0, .0, .0, ]nonadec-9-ene-4, 11-dione
Smiles :
CC1=CC(=O)[C@@H](O)[C@@]2(C)[C@H]1C[C@H]1OC(=O)[C@H](O)[C@]3(O)[C@@]41CO[C@]3(C)[C@@H](O)[C@H](O)[C@H]24
InChiKey:
JBDMZGKDLMGOFR-KQSRGDCESA-N
InChi :
InChI=1S/C20H26O9/c1-7-4-9(21)13(23)17(2)8(7)5-10-19-6-28-18(3,14(24)11(22)12(17)19)20(19,27)15(25)16(26)29-10/h4,8,10-15,22-25,27H,5-6H2,1-3H3/t8-,10+,11+,12+,13+,14-,15-,17-,18+,19+,20+/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Bruceine D is a Notch inhibitor with anti-cancer activity and induces apoptosis in several human cancer cells. Bruceine D is an effective botanical insect antifeedant with outstanding systemic properties, causing potent pest growth inhibitory activity.{{Hydroxyurea} web|{Hydroxyurea} Apoptosis|{Hydroxyurea} Purity & Documentation|{Hydroxyurea} Purity|{Hydroxyurea} custom synthesis|{Hydroxyurea} Epigenetics} Bruceine D has strong anthelmintic activity against D. intermedius with an EC50 value of 0.57 mg/L.|Product information|CAS Number: 21499-66-1|Molecular Weight: 410.42|Formula: C20H26O9|Chemical Name: (1R, 2R, 3R, 6R, 8S, 12S, 13S, 14R, 15R, 16S, 17R)-2, 3, 12, 15, 16-pentahydroxy-9, 13, 17-trimethyl-5, 18-dioxapentacyclo[12.5.0.0, .0, .0, ]nonadec-9-ene-4, 11-dione|Smiles: CC1=CC(=O)[C@@H](O)[C@@]2(C)[C@H]1C[C@H]1OC(=O)[C@H](O)[C@]3(O)[C@@]41CO[C@]3(C)[C@@H](O)[C@H](O)[C@H]24|InChiKey: JBDMZGKDLMGOFR-KQSRGDCESA-N|InChi: InChI=1S/C20H26O9/c1-7-4-9(21)13(23)17(2)8(7)5-10-19-6-28-18(3,14(24)11(22)12(17)19)20(19,27)15(25)16(26)29-10/h4,8,10-15,22-25,27H,5-6H2,1-3H3/t8-,10+,11+,12+,13+,14-,15-,17-,18+,19+,20+/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (243.{{Zoliflodacin} site|{Zoliflodacin} Antibiotic|{Zoliflodacin} Biological Activity|{Zoliflodacin} In Vivo|{Zoliflodacin} supplier|{Zoliflodacin} Autophagy} 65 mM; Need ultrasonic)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:33103500 |Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Bruceine D inhibits the cell viability of H460 and A549 cells in a dose-dependent manner with IC50 values of 0.5 and 0.6 μM, respectively, at 48 h of treatment. Bruceine D (0.125-1.0 μM) dose-dependently promotes chromatin condensation, Annexin V-positive cell population and caspase-dependent apoptosis in H460 and A549 cells.|References:|Mao G,et al. Bruceine D Isolated from Brucea Javanica (L.) Merr. as a Systemic Feeding Deterrent for Three Major Lepidopteran Pests. J Agric Food Chem. 2019 Apr 17;67(15):4232-4239.Yong Wang, et al. In vivo anthelmintic activity of bruceine A and bruceine D from Brucea javanica against Dactylogyrus intermedius (Monogenea) in goldfish (Carassius auratus). Vet Parasitol. 2011 Apr 19;177(1-2):127-33.Products are for research use only. Not for human use.|