Product Name :
Lanoconazole
Description:
Lanoconazole is a potent and orally active imidazole antifungal agent, shows a broad spectrum of activity against fungi in vitro and in vivo. Lanoconazole interferes with ergosterol biosynthesis by inhibiting sterol 14-alpha demethylase and blocking fungal membrane ergosterol biosynthesis. Lanoconazole can be used for the investigation of dermatophytosis and onychomycosis.
CAS:
101530-10-3
Molecular Weight:
319.83
Formula:
C14H10ClN3S2
Chemical Name:
2-[(2E)-4-(2-chlorophenyl)-1,3-dithiolan-2-ylidene]-2-(1H-imidazol-1-yl)acetonitrile
Smiles :
N#C/C(=C1/SCC(S/1)C1=CC=CC=C1Cl)/N1C=CN=C1
InChiKey:
ZRTQSJFIDWNVJW-WYMLVPIESA-N
InChi :
InChI=1S/C14H10ClN3S2/c15-11-4-2-1-3-10(11)13-8-19-14(20-13)12(7-16)18-6-5-17-9-18/h1-6,9,13H,8H2/b14-12+
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Zileuton} web|{Zileuton} Apoptosis|{Zileuton} Biological Activity|{Zileuton} Purity|{Zileuton} custom synthesis|{Zileuton} Autophagy}
Additional information:
Lanoconazole is a potent and orally active imidazole antifungal agent, shows a broad spectrum of activity against fungi in vitro and in vivo.{{Ciclopirox} MedChemExpress|{Ciclopirox} Fungal|{Ciclopirox} Protocol|{Ciclopirox} In Vitro|{Ciclopirox} manufacturer|{Ciclopirox} Epigenetic Reader Domain} Lanoconazole interferes with ergosterol biosynthesis by inhibiting sterol 14-alpha demethylase and blocking fungal membrane ergosterol biosynthesis.PMID:32037923 Lanoconazole can be used for the investigation of dermatophytosis and onychomycosis.|Product information|CAS Number: 101530-10-3|Molecular Weight: 319.83|Formula: C14H10ClN3S2|Chemical Name: 2-[(2E)-4-(2-chlorophenyl)-1,3-dithiolan-2-ylidene]-2-(1H-imidazol-1-yl)acetonitrile|Smiles: N#C/C(=C1/SCC(S/1)C1=CC=CC=C1Cl)/N1C=CN=C1|InChiKey: ZRTQSJFIDWNVJW-WYMLVPIESA-N|InChi: InChI=1S/C14H10ClN3S2/c15-11-4-2-1-3-10(11)13-8-19-14(20-13)12(7-16)18-6-5-17-9-18/h1-6,9,13H,8H2/b14-12+|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (312.67 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|Lanoconazole (treatment for ear; 0.3%-3%; 6 days) dose‐dependently suppressesTPA-induced irritant dermatitis, suppresses the production of neutrophil chemotactic factors such as keratinocyte‐derived chemokine and macrophage inflammatory protein‐2, and inhibited neutrophil infiltration to the inflammation site. Lanoconazole (oral administration; 3, 10 or 30 mg/kg; once a day; 3 weeks) significantly inhibits C. neoformans compared with the saline control in normal mice. In addtion, it significantly reduces the growth of C. neoformans in the lungs and brains of MAIDS mice.|Products are for research use only. Not for human use.|