Product Name :
Niraparib metabolite M1
Description:
Niraparib metabolite M1 is a metabolite of niraparib, and the latter one acts as a novel poly(ADP-Ribose) polymerase (PARP) inhibitor.
CAS:
1476777-06-6
Molecular Weight:
321.37
Formula:
C19H19N3O2
Chemical Name:
2-4-[(3S)-piperidin-3-yl]phenyl-2H-indazole-7-carboxylic acid
Smiles :
OC(=O)C1=CC=CC2=CN(N=C21)C1C=CC(=CC=1)[C@H]1CNCCC1
InChiKey:
HDQHGRLURKGIFL-CQSZACIVSA-N
InChi :
InChI=1S/C19H19N3O2/c23-19(24)17-5-1-3-15-12-22(21-18(15)17)16-8-6-13(7-9-16)14-4-2-10-20-11-14/h1,3,5-9,12,14,20H,2,4,10-11H2,(H,23,24)/t14-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.Lonigutamab Cancer
Additional information:
Niraparib metabolite M1 is a metabolite of niraparib, and the latter one acts as a novel poly(ADP-Ribose) polymerase (PARP) inhibitor.Quinine Epigenetic Reader Domain |Product information|CAS Number: 1476777-06-6|Molecular Weight: 321.37|Formula: C19H19N3O2|Synonym:|Niraparib carboxylic acid metabolite M1|M1 metabolite of niraparib|Chemical Name: 2-4-[(3S)-piperidin-3-yl]phenyl-2H-indazole-7-carboxylic acid|Smiles: OC(=O)C1=CC=CC2=CN(N=C21)C1C=CC(=CC=1)[C@H]1CNCCC1|InChiKey: HDQHGRLURKGIFL-CQSZACIVSA-N|InChi: InChI=1S/C19H19N3O2/c23-19(24)17-5-1-3-15-12-22(21-18(15)17)16-8-6-13(7-9-16)14-4-2-10-20-11-14/h1,3,5-9,12,14,20H,2,4,10-11H2,(H,23,24)/t14-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 100 mg/mL (311.17 mM).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:33356596 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Niraparib metabolite M1 has the validation in plasma and urine for the support of clinical studies such as the mass balance study and the absolute bioavailability study.|References:|van Andel L, et al. Liquid chromatography-tandem mass spectrometry assay for the quantification of niraparib and its metabolite M1 in human plasma and urine. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Nov 19;1040:14-21Products are for research use only. Not for human use.|