Product Name :
Alofanib
Description:
Alofanib (RPT835) is a potent and selective allosteric inhibitor of fibroblast growth factor receptor 2 (FGFR2). Anticancer and antiangiogenic activity.
CAS:
1612888-66-0
Molecular Weight:
413.40
Formula:
C19H15N3O6S
Chemical Name:
3-[4-methyl-2-nitro-5-(pyridin-3-yl)phenyl]sulfamoylbenzoic acid
Smiles :
CC1C=C(C(=CC=1C1C=NC=CC=1)NS(=O)(=O)C1=CC(=CC=C1)C(O)=O)[N+]([O-])=O
InChiKey:
QUQGQIASFYWKAB-UHFFFAOYSA-N
InChi :
InChI=1S/C19H15N3O6S/c1-12-8-18(22(25)26)17(10-16(12)14-5-3-7-20-11-14)21-29(27,28)15-6-2-4-13(9-15)19(23)24/h2-11,21H,1H3,(H,23,24)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.DOTMA Metabolic Enzyme/Protease
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Alofanib (RPT835) is a potent and selective allosteric inhibitor of fibroblast growth factor receptor 2 (FGFR2). Anticancer and antiangiogenic activity.|Product information|CAS Number: 1612888-66-0|Molecular Weight: 413.40|Formula: C19H15N3O6S|Chemical Name: 3-[4-methyl-2-nitro-5-(pyridin-3-yl)phenyl]sulfamoylbenzoic acid|Smiles: CC1C=C(C(=CC=1C1C=NC=CC=1)NS(=O)(=O)C1=CC(=CC=C1)C(O)=O)[N+]([O-])=O|InChiKey: QUQGQIASFYWKAB-UHFFFAOYSA-N|InChi: InChI=1S/C19H15N3O6S/c1-12-8-18(22(25)26)17(10-16(12)14-5-3-7-20-11-14)21-29(27,28)15-6-2-4-13(9-15)19(23)24/h2-11,21H,1H3,(H,23,24)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 30.1 mg/mL (72.81 mM).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Tafamidis Neuronal Signaling |Shelf Life: ≥12 months if stored properly.PMID:32301491 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Alofanib inhibits phosphorylation of FRS2α with IC50s of 7 and 9 nM in hFOB and SUM 52PE cells expressing different FGFR2 isoforms.|In Vivo:|In a FGFR-driven human tumour xenograft model, oral administration of alofanib (30 mg/kg,gavage, daily, 40 days, N=10) is well tolerated and results in potent antitumour activity.|Products are for research use only. Not for human use.|