Product Name :
BAF312 (Siponimod)
Description:
BAF312 is a potent and selective agonist of S1P with EC50 value of 0.39nM for S1P1 receptors and 0.98nM for S1P5 receptors, respectively . BAF312 has shown >1000-fold selectivity for S1P1 versus S1P2, S1P3 and S1P4 receptors . In vitro metabolism studies with liver microsomes have shown that the metabolic clearance of BAF312 is high in rat, low to moderate in monkey and human being, and low in dog and mouse. Moreover, BAF312 has been revealed to dose-dependently reduce peripheral lymphocyte counts in Lewis rats . . .
CAS:
1230487-00-9
Molecular Weight:
516.60
Formula:
C29H35F3N2O3
Chemical Name:
1-({4-[1-({[4-cyclohexyl-3-(trifluoromethyl)phenyl]methoxy}imino)ethyl]-2-ethylphenyl}methyl)azetidine-3-carboxylic acid
Smiles :
CC(=NOCC1=CC(=C(C=C1)C1CCCCC1)C(F)(F)F)C1C=CC(CN2CC(C2)C(O)=O)=C(CC)C=1
InChiKey:
KIHYPELVXPAIDH-HNSNBQBZSA-N
InChi :
InChI=1S/C29H35F3N2O3/c1-3-21-14-23(10-11-24(21)15-34-16-25(17-34)28(35)36)19(2)33-37-18-20-9-12-26(22-7-5-4-6-8-22)27(13-20)29(30,31)32/h9-14,22,25H,3-8,15-18H2,1-2H3,(H,35,36)/b33-19+
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.{{Ramelteon} MedChemExpress|{Ramelteon} Neuronal Signaling|{Ramelteon} Biological Activity|{Ramelteon} References|{Ramelteon} manufacturer|{Ramelteon} Epigenetic Reader Domain}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Tofacitinib} MedChemExpress|{Tofacitinib} Stem Cell/Wnt|{Tofacitinib} Purity & Documentation|{Tofacitinib} In Vivo|{Tofacitinib} supplier|{Tofacitinib} Epigenetics}
Additional information:
BAF312 is a potent and selective agonist of S1P with EC50 value of 0.PMID:23907051 39nM for S1P1 receptors and 0.98nM for S1P5 receptors, respectively . BAF312 has shown >1000-fold selectivity for S1P1 versus S1P2, S1P3 and S1P4 receptors . In vitro metabolism studies with liver microsomes have shown that the metabolic clearance of BAF312 is high in rat, low to moderate in monkey and human being, and low in dog and mouse. Moreover, BAF312 has been revealed to dose-dependently reduce peripheral lymphocyte counts in Lewis rats . . .|Product information|CAS Number: 1230487-00-9|Molecular Weight: 516.60|Formula: C29H35F3N2O3|Chemical Name: 1-({4-[1-({[4-cyclohexyl-3-(trifluoromethyl)phenyl]methoxy}imino)ethyl]-2-ethylphenyl}methyl)azetidine-3-carboxylic acid|Smiles: CC(=NOCC1=CC(=C(C=C1)C1CCCCC1)C(F)(F)F)C1C=CC(CN2CC(C2)C(O)=O)=C(CC)C=1|InChiKey: KIHYPELVXPAIDH-HNSNBQBZSA-N|InChi: InChI=1S/C29H35F3N2O3/c1-3-21-14-23(10-11-24(21)15-34-16-25(17-34)28(35)36)19(2)33-37-18-20-9-12-26(22-7-5-4-6-8-22)27(13-20)29(30,31)32/h9-14,22,25H,3-8,15-18H2,1-2H3,(H,35,36)/b33-19+|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|