Product Name :
DB07107
Description:
DB07107 is a potent drug resistant T315I mutant Bcr-Abl tyrosine kinase inhibitor. DB07107 is also a potent Akt1 inhibitor with an IC50 value of 360 nM.
CAS:
552332-71-5
Molecular Weight:
370.45
Formula:
C23H22N4O
Chemical Name:
(2R)-1-(1H-indol-3-yl)-3-({5-[(E)-2-(pyridin-4-yl)ethenyl]pyridin-3-yl}oxy)propan-2-amine
Smiles :
N[C@H](CC1=CNC2=CC=CC=C12)COC1C=NC=C(C=1)/C=C/C1C=CN=CC=1
InChiKey:
SGHXFHRRWFLILP-RRFGBZISSA-N
InChi :
InChI=1S/C23H22N4O/c24-20(12-19-14-27-23-4-2-1-3-22(19)23)16-28-21-11-18(13-26-15-21)6-5-17-7-9-25-10-8-17/h1-11,13-15,20,27H,12,16,24H2/b6-5+/t20-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Adipolean/gAcrp30 Protein, Human (CHO)} MedChemExpress|{Adipolean/gAcrp30 Protein, Human (CHO)} Technical Information|{Adipolean/gAcrp30 Protein, Human (CHO)} In Vivo|{Adipolean/gAcrp30 Protein, Human (CHO)} custom synthesis|{Adipolean/gAcrp30 Protein, Human (CHO)} Autophagy}
Shelf Life:
≥12 months if stored properly.{{Galcuronokinase} medchemexpress|{Galcuronokinase} Ferroptosis|{Galcuronokinase} Purity & Documentation|{Galcuronokinase} Data Sheet|{Galcuronokinase} custom synthesis|{Galcuronokinase} Autophagy}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:24516446
Additional information:
DB07107 is a potent drug resistant T315I mutant Bcr-Abl tyrosine kinase inhibitor. DB07107 is also a potent Akt1 inhibitor with an IC50 value of 360 nM.|Product information|CAS Number: 552332-71-5|Molecular Weight: 370.45|Formula: C23H22N4O|Chemical Name: (2R)-1-(1H-indol-3-yl)-3-({5-[(E)-2-(pyridin-4-yl)ethenyl]pyridin-3-yl}oxy)propan-2-amine|Smiles: N[C@H](CC1=CNC2=CC=CC=C12)COC1C=NC=C(C=1)/C=C/C1C=CN=CC=1|InChiKey: SGHXFHRRWFLILP-RRFGBZISSA-N|InChi: InChI=1S/C23H22N4O/c24-20(12-19-14-27-23-4-2-1-3-22(19)23)16-28-21-11-18(13-26-15-21)6-5-17-7-9-25-10-8-17/h1-11,13-15,20,27H,12,16,24H2/b6-5+/t20-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|DB07107 is more effective in blocking drug-resistant T315I mutant than the wild-type Bcr-Abl. DB07107 (C23H22N4O) from DrugBank showed the highest binding energy with XP score of -14.045 kcal/mol.|Products are for research use only. Not for human use.|