Product Name :
Neogambogic acid
Description:
Neogambogic acid, an active ingredient in garcinia, induces apoptosis and has anticancer effect. Neogambogic acid has significant inhibitory activity toward methicillin-resistant Staphylococcus aureus (MRSA).
CAS:
93772-31-7
Molecular Weight:
646.77
Formula:
C38H46O9
Chemical Name:
(2E)-4-[10,12-dihydroxy-8,21,21-trimethyl-5-(3-methylbut-2-en-1-yl)-8-(4-methylpent-3-en-1-yl)-14,18-dioxo-3,7,20-trioxahexacyclo[15.4.1.0²,¹⁵.0²,¹⁹.0⁴,¹³.0⁶,¹¹]docosa-4(13),5,11,15-tetraen-19-yl]-2-methylbut-2-enoic acid
Smiles :
CC1(C)OC2(C/C=C(\C)/C(O)=O)C(=O)C3CC1C12OC2=C(C(=O)C1=C3)C(O)=C1C(O)CC(C)(CCC=C(C)C)OC1=C2CC=C(C)C
InChiKey:
BLDWFKHVHHINGR-FYJGNVAPSA-N
InChi :
InChI=1S/C38H46O9/c1-19(2)10-9-14-36(8)18-25(39)27-30(41)28-29(40)24-16-22-17-26-35(6,7)47-37(33(22)42,15-13-21(5)34(43)44)38(24,26)46-32(28)23(31(27)45-36)12-11-20(3)4/h10-11,13,16,22,25-26,39,41H,9,12,14-15,17-18H2,1-8H3,(H,43,44)/b21-13+
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Ifosfamide} MedChemExpress|{Ifosfamide} DNA Alkylator/Crosslinker|{Ifosfamide} Protocol|{Ifosfamide} In Vitro|{Ifosfamide} manufacturer|{Ifosfamide} Epigenetic Reader Domain}
Shelf Life:
≥12 months if stored properly.{{Enalapril} medchemexpress|{Enalapril} Metabolic Enzyme/Protease|{Enalapril} Biological Activity|{Enalapril} Purity|{Enalapril} manufacturer|{Enalapril} Autophagy}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23865629
Additional information:
Neogambogic acid, an active ingredient in garcinia, induces apoptosis and has anticancer effect. Neogambogic acid has significant inhibitory activity toward methicillin-resistant Staphylococcus aureus (MRSA).|Product information|CAS Number: 93772-31-7|Molecular Weight: 646.77|Formula: C38H46O9|Chemical Name: (2E)-4-[10,12-dihydroxy-8,21,21-trimethyl-5-(3-methylbut-2-en-1-yl)-8-(4-methylpent-3-en-1-yl)-14,18-dioxo-3,7,20-trioxahexacyclo[15.4.1.0²,¹⁵.0²,¹⁹.0⁴,¹³.0⁶,¹¹]docosa-4(13),5,11,15-tetraen-19-yl]-2-methylbut-2-enoic acid|Smiles: CC1(C)OC2(C/C=C(\C)/C(O)=O)C(=O)C3CC1C12OC2=C(C(=O)C1=C3)C(O)=C1C(O)CC(C)(CCC=C(C)C)OC1=C2CC=C(C)C|InChiKey: BLDWFKHVHHINGR-FYJGNVAPSA-N|InChi: InChI=1S/C38H46O9/c1-19(2)10-9-14-36(8)18-25(39)27-30(41)28-29(40)24-16-22-17-26-35(6,7)47-37(33(22)42,15-13-21(5)34(43)44)38(24,26)46-32(28)23(31(27)45-36)12-11-20(3)4/h10-11,13,16,22,25-26,39,41H,9,12,14-15,17-18H2,1-8H3,(H,43,44)/b21-13+|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Neogambogic acid inhibits HCT-8, Bel-7402, BGC-823, A549, and A2780 cell proliferation, with an IC50 between 1.75 and 3 μM. Neogambogic acid induces A549 cells apoptosis arrested the cells to G0/G1 phase in vitro.|In Vivo:|Neogambogic acid arrests A549-induced tumor growth in nude mice.|Products are for research use only. Not for human use.|