Product Name :
FPPQ
Description:
FPPQ is a Dual-Acting 5‑HT3 (K1 = 0.9 nM) and 5‑HT6 (Ki = 3 nM) Receptor Antagonist with Antipsychotic and Procognitive Properties. FPPQ behaves as a 5-HT3R antagonist and a neutral antagonist 5-HT6R of the Gs pathway. FPPQ shows selectivity over 87 targets and decent brain penetration. Likewise, FPPQ inhibits phencyclidine (PCP)-induced hyperactivity and displays procognitive properties in the novel object recognition task. FPPQ is a dual-acting 5-HT3 (Ki = 0.9 nM) and 5-HT6 (Ki = 3 nM) receptor antagonist with antipsychotic and procognitive properties.
CAS:
1648745-46-3
Molecular Weight:
410.46
Formula:
C21H19FN4O2S
Chemical Name:
1-[1-(3-fluorobenzenesulfonyl)-1H-pyrrolo[3, 2-c]quinolin-4-yl]piperazine
Smiles :
O=S(=O)(C1=CC(F)=CC=C1)N1C=CC2=C(N=C3C=CC=CC3=C12)N1CCNCC1
InChiKey:
QNKGTIWNFNPEJL-UHFFFAOYSA-N
InChi :
InChI=1S/C21H19FN4O2S/c22-15-4-3-5-16(14-15)29(27,28)26-11-8-18-20(26)17-6-1-2-7-19(17)24-21(18)25-12-9-23-10-13-25/h1-8,11,14,23H,9-10,12-13H2
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Leniolisib} site|{Leniolisib} PI3K|{Leniolisib} Protocol|{Leniolisib} References|{Leniolisib} manufacturer|{Leniolisib} Cancer}
Shelf Life:
≥12 months if stored properly.{{DBCO-NHS ester} MedChemExpress|{DBCO-NHS ester} ADC Linker|{DBCO-NHS ester} Biological Activity|{DBCO-NHS ester} In Vivo|{DBCO-NHS ester} custom synthesis|{DBCO-NHS ester} Autophagy}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:24140575
Additional information:
FPPQ is a Dual-Acting 5‑HT3 (K1 = 0.9 nM) and 5‑HT6 (Ki = 3 nM) Receptor Antagonist with Antipsychotic and Procognitive Properties. FPPQ behaves as a 5-HT3R antagonist and a neutral antagonist 5-HT6R of the Gs pathway. FPPQ shows selectivity over 87 targets and decent brain penetration. Likewise, FPPQ inhibits phencyclidine (PCP)-induced hyperactivity and displays procognitive properties in the novel object recognition task. FPPQ is a dual-acting 5-HT3 (Ki = 0.9 nM) and 5-HT6 (Ki = 3 nM) receptor antagonist with antipsychotic and procognitive properties.|Product information|CAS Number: 1648745-46-3|Molecular Weight: 410.46|Formula: C21H19FN4O2S|Chemical Name: 1-[1-(3-fluorobenzenesulfonyl)-1H-pyrrolo[3, 2-c]quinolin-4-yl]piperazine|Smiles: O=S(=O)(C1=CC(F)=CC=C1)N1C=CC2=C(N=C3C=CC=CC3=C12)N1CCNCC1|InChiKey: QNKGTIWNFNPEJL-UHFFFAOYSA-N|InChi: InChI=1S/C21H19FN4O2S/c22-15-4-3-5-16(14-15)29(27,28)26-11-8-18-20(26)17-6-1-2-7-19(17)24-21(18)25-12-9-23-10-13-25/h1-8,11,14,23H,9-10,12-13H2|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: To be determined|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Zajdel P, et al. Structure-Based Design and Optimization of FPPQ, a Dual-Acting 5-HT3 and 5-HT6 Receptor Antagonist with Antipsychotic and Procognitive Properties. J Med Chem. 2021 Sep 23;64(18):13279-13298.Products are for research use only. Not for human use.|