Product Name :
Flutamide
Description:
Flutamide, also known as SCH13521, is a toluidine derivative and nonsteroidal antiandrogen that is structurally related to bicalutamide and nilutamide. Flutamide and its more potent active metabolite 2-hydroxyflutamide competitively block dihydrotestosterone binding at androgen receptors, forming inactive complexes which cannot translocate into the cell nucleus. Formation of inactive receptors inhibits androgen-dependent DNA and protein synthesis, resulting in tumor cell growth arrest or transient tumor regression. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).
CAS:
13311-84-7
Molecular Weight:
276.21
Formula:
C11H11F3N2O3
Chemical Name:
N-(4-nitro-3-(trifluoromethyl)phenyl)isobutyramide
Smiles :
CC(C)C(=O)NC1=CC(=C(C=C1)[N+]([O-])=O)C(F)(F)F
InChiKey:
MKXKFYHWDHIYRV-UHFFFAOYSA-N
InChi :
InChI=1S/C11H11F3N2O3/c1-6(2)10(17)15-7-3-4-9(16(18)19)8(5-7)11(12,13)14/h3-6H,1-2H3,(H,15,17)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Flutamide, also known as SCH13521, is a toluidine derivative and nonsteroidal antiandrogen that is structurally related to bicalutamide and nilutamide. Flutamide and its more potent active metabolite 2-hydroxyflutamide competitively block dihydrotestosterone binding at androgen receptors, forming inactive complexes which cannot translocate into the cell nucleus. Formation of inactive receptors inhibits androgen-dependent DNA and protein synthesis, resulting in tumor cell growth arrest or transient tumor regression. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).|Product information|CAS Number: 13311-84-7|Molecular Weight: 276.21|Formula: C11H11F3N2O3|Synonym:|SCH-13521|SCH13521 |SCH-13521 |SCH 13521 |Flucinom |Flugerel|Niftolid |Eulexin |Apimid |Chimax |Drogenil|Euflex |Eulexine |Flucinome |Fluken |Flulem|Flutabene |Flutacan|FlutaGry|Flutamex|Flutamin|Flutan|Flutaplex|Fugerel|Grisetin|Oncosal|Profamid|Prostacur|Prostadirex|Prostica|Prostogenat|Tafenil|Tecnoflut|Testotard|FLUT|Chemical Name: N-(4-nitro-3-(trifluoromethyl)phenyl)isobutyramide|Smiles: CC(C)C(=O)NC1=CC(=C(C=C1)[N+]([O-])=O)C(F)(F)F|InChiKey: MKXKFYHWDHIYRV-UHFFFAOYSA-N|InChi: InChI=1S/C11H11F3N2O3/c1-6(2)10(17)15-7-3-4-9(16(18)19)8(5-7)11(12,13)14/h3-6H,1-2H3,(H,15,17)|Technical Data|Appearance: Solid Power.{{Protocatechuate 3,4-dioxygenase} medchemexpress|{Protocatechuate 3,4-dioxygenase} Purity & Documentation|{Protocatechuate 3,4-dioxygenase} Purity|{Protocatechuate 3,4-dioxygenase} manufacturer|{Protocatechuate 3,4-dioxygenase} Cancer} |Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO, not in water|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Ibezapolstat} web|{Ibezapolstat} DNA/RNA Synthesis|{Ibezapolstat} Purity & Documentation|{Ibezapolstat} In stock|{Ibezapolstat} supplier|{Ibezapolstat} Cancer} |Shelf Life: ≥12 months if stored properly.PMID:25818744 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined.|HS Tariff Code: 382200|References:|Simard J, et al. Characteristics of interaction of the antiandrogen flutamide with the androgen receptor in various target tissues. Mol Cell Endocrinol. 1986 Mar;44(3):261-70.Luthy IA, et al. Androgenic activity of synthetic progestins and spironolactone in androgen-sensitive mouse mammary carcinoma (Shionogi) cells in culture. J Steroid Biochem. 1988 Nov;31(5):845-52.Crawford ED, et al. A controlled trial of leuprolide with and without flutamide in prostatic carcinoma. N Engl J Med. 1989 Aug 17;321(7):419-24.Products are for research use only. Not for human use.|