Product Name :
Physostigmine hemisulfate
Description:
Physostigmine hemisulfate (Eserine hemisulfate) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine hemisulfate can crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine hemisulfate can reverse memory deficits in transgenic mice with Alzheimer’s disease. Physostigmine hemisulfate is also an antidote for anticholinergic poisoning.
CAS:
64-47-1
Molecular Weight:
648.77
Formula:
C30H44N6O8S
Chemical Name:
bis((E)-1-{[(3aS,8aR)-1,3a,8-trimethyl-1H,2H,3H,3aH,8H,8aH-pyrrolo[2,3-b]indol-5-yl]oxy}-N-methylmethanimidic acid); sulfuric acid
Smiles :
C[C@@]12CCN(C)[C@@H]1N(C)C1C=CC(=CC2=1)O/C(/O)=N/C.C[C@@]12CCN(C)[C@@H]1N(C)C1C=CC(=CC2=1)O/C(/O)=N/C.OS(O)(=O)=O
InChiKey:
YYBNDIVPHIWTPK-KYJQVDHRSA-N
InChi :
InChI=1S/2C15H21N3O2.H2O4S/c2*1-15-7-8-17(3)13(15)18(4)12-6-5-10(9-11(12)15)20-14(19)16-2;1-5(2,3)4/h2*5-6,9,13H,7-8H2,1-4H3,(H,16,19);(H2,1,2,3,4)/t2*13-,15+;/m11./s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Physostigmine hemisulfate (Eserine hemisulfate) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine hemisulfate can crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine hemisulfate can reverse memory deficits in transgenic mice with Alzheimer’s disease. Physostigmine hemisulfate is also an antidote for anticholinergic poisoning.|Product information|CAS Number: 64-47-1|Molecular Weight: 648.77|Formula: C30H44N6O8S|Chemical Name: bis((E)-1-{[(3aS,8aR)-1,3a,8-trimethyl-1H,2H,3H,3aH,8H,8aH-pyrrolo[2,3-b]indol-5-yl]oxy}-N-methylmethanimidic acid); sulfuric acid|Smiles: C[C@@]12CCN(C)[C@@H]1N(C)C1C=CC(=CC2=1)O/C(/O)=N/C.C[C@@]12CCN(C)[C@@H]1N(C)C1C=CC(=CC2=1)O/C(/O)=N/C.OS(O)(=O)=O|InChiKey: YYBNDIVPHIWTPK-KYJQVDHRSA-N|InChi: InChI=1S/2C15H21N3O2.H2O4S/c2*1-15-7-8-17(3)13(15)18(4)12-6-5-10(9-11(12)15)20-14(19)16-2;1-5(2,3)4/h2*5-6,9,13H,7-8H2,1-4H3,(H,16,19);(H2,1,2,3,4)/t2*13-,15+;/m11.{{Propranolol} medchemexpress|{Propranolol} GPCR/G Protein|{Propranolol} Technical Information|{Propranolol} Formula|{Propranolol} custom synthesis|{Propranolol} Epigenetics} /s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Mosapride} MedChemExpress|{Mosapride} Cytochrome P450|{Mosapride} Protocol|{Mosapride} Formula|{Mosapride} supplier|{Mosapride} Cancer} |Shelf Life: ≥12 months if stored properly.PMID:35901518 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|Physostigmine hemisulfate (Eserine hemisulfate; 0.03-0.3 mg/kg; s.c.; daily for 6 weeks) improves deficits in contextual and cued memory in Tg(+) mice. Physostigmine hemisulfate (IV; 0.1, 0.2 mg/kg) delays time to emergence from isoflurane anesthesia at doses ≥0.2 mg/kg in male Sprague-Dawley rats.|Products are for research use only. Not for human use.|