Product Name :
Dehydroaltenusin
Description:
Dehydroaltenusin is a small molecule selective inhibitor of eukaryotic DNA polymerase α, a type of antibiotic produced by a fungus with an IC50 value of 0.68 μM. The inhibitory mode of action of dehydroaltenusin against mammalian pol α activity is competitive with respect to the DNA template primer (Ki=0.23 µM) and non-competitive with respect to the 2′-deoxyribonucleoside 5′-triphosphate substrate (Ki=0.18 µM). Dehydroaltenusin arrests the cancer cell cycle at the S-phase and triggers apoptosis. Dehydroaltenusin possesses anti-tumor activity against human adenocarcinoma tumor in vivo.
CAS:
31186-13-7
Molecular Weight:
288.25
Formula:
C15H12O6
Chemical Name:
(4aS)-3,7-dihydroxy-9-methoxy-4a-methyl-2H,4aH,6H-benzo[c]chromene-2,6-dione
Smiles :
COC1=CC2=C(C(=O)O[C@@]3(C)C=C(O)C(=O)C=C32)C(O)=C1
InChiKey:
YWYZLBQRCUAQAV-HNNXBMFYSA-N
InChi :
InChI=1S/C15H12O6/c1-15-6-12(18)10(16)5-9(15)8-3-7(20-2)4-11(17)13(8)14(19)21-15/h3-6,17-18H,1-2H3/t15-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Beta Actin Mouse mAb} MedChemExpress|{Beta Actin Mouse mAb} Purity & Documentation|{Beta Actin Mouse mAb} Purity|{Beta Actin Mouse mAb} custom synthesis|{Beta Actin Mouse mAb} Epigenetic Reader Domain}
Shelf Life:
≥12 months if stored properly.{{Cipargamin} MedChemExpress|{Cipargamin} Inhibitor|{Cipargamin} NF-κB|{Cipargamin} Technical Information|{Cipargamin} Formula|{Cipargamin} manufacturer}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:33021531
Additional information:
Dehydroaltenusin is a small molecule selective inhibitor of eukaryotic DNA polymerase α, a type of antibiotic produced by a fungus with an IC50 value of 0.68 μM. The inhibitory mode of action of dehydroaltenusin against mammalian pol α activity is competitive with respect to the DNA template primer (Ki=0.23 µM) and non-competitive with respect to the 2′-deoxyribonucleoside 5′-triphosphate substrate (Ki=0.18 µM). Dehydroaltenusin arrests the cancer cell cycle at the S-phase and triggers apoptosis. Dehydroaltenusin possesses anti-tumor activity against human adenocarcinoma tumor in vivo.|Product information|CAS Number: 31186-13-7|Molecular Weight: 288.25|Formula: C15H12O6|Chemical Name: (4aS)-3,7-dihydroxy-9-methoxy-4a-methyl-2H,4aH,6H-benzo[c]chromene-2,6-dione|Smiles: COC1=CC2=C(C(=O)O[C@@]3(C)C=C(O)C(=O)C=C32)C(O)=C1|InChiKey: YWYZLBQRCUAQAV-HNNXBMFYSA-N|InChi: InChI=1S/C15H12O6/c1-15-6-12(18)10(16)5-9(15)8-3-7(20-2)4-11(17)13(8)14(19)21-15/h3-6,17-18H,1-2H3/t15-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Dehydroaltenusin (38.0-44.4 μM; 24 hours) inhibits cell growth in a dose-dependent manner and the LD50 values varies from 38.0 to 44.4 μM. Dehydroaltenusin (38.0 μM; 6 hours) inhibits cell growth by blocking the S-phase of DNA replication. Dehydroaltenusin (75.0 μM; 24 hours) has a strong apoptotic effect on human cancer cells, DNA ladders can be detected after 12 h of incubation with dehydroaltenusin.|In Vivo:|Dehydroaltenusin (injection; 20 mg/kg; 2-day intervals; 12-39 days) shows suppressed tumor growth from 21 days.|Products are for research use only. Not for human use.|