Product Name :
Paxilline

Sequence:

Purity:
≥97% (HPLC)

Molecular Weight:
435.6

Solubility :
Soluble in DMSO (50mg/ml).

Appearance:
White solid.

Use/Stability :
As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.

Description:
K+ channel blocker Paxilline is an indole alkaloid isolated from Penicillium paxilli. It is a selective and reversible blocker of the smooth muscle high conductance Ca2+-activated K+ (maxi-K) channel (70% block at 10 nM). In neutrophils, Paxilline blockage of BKCa channels decreased the alkalinization of phagocytic vacuoles and inhibited the microbicidal process. Inhibitor of the cerebellar inositol 1,4,5-triphosphate (InsP(3)) receptor.{{1650599-68-0} MedChemExpress|{1650599-68-0} Purity & Documentation|{1650599-68-0} References|{1650599-68-0} supplier}

CAS :
57186-25-1

Solubility:
Soluble in DMSO (50mg/ml).{{76410-58-7} site|{76410-58-7} Technical Information|{76410-58-7} Description|{76410-58-7} supplier}

Formula:
C27H33NO4

Additional Information :
| Appearance White solid.PMID:29939522 | CAS 57186-25-1 | Couple Target IP3 receptor, Potassium channel | Couple Type Blocker, Ligand | Formula C27H33NO4 | MW 435.6 | Purity ≥97% (HPLC) | RTECS DJ2830000 | Solubility Soluble in DMSO (50mg/ml). | Unit of Measure (UM) mg

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