Product Name :
Sterigmatocystine
Description:
Sterigmatocystine is a precursor of aflatoxins and a mycotoxin produced by common mold strains from Aspergillus versicolor. Sterigmatocystine, a inhibitor of G1 Phase and DNA synthesis, is used to inhibit p21 activity. Sterigmatocystine has teratogenic, and carcinogenic effects in animals.
CAS:
10048-13-2
Molecular Weight:
324.28
Formula:
C18H12O6
Chemical Name:
(3S, 7R)-15-hydroxy-11-methoxy-6, 8, 20-trioxapentacyclo[10.8.0.0, .0, .0, ]icosa-1(12), 2(9), 4, 10, 14(19), 15, 17-heptaen-13-one
Smiles :
COC1=CC2O[C@H]3OC=C[C@H]3C=2C2OC3=CC=CC(O)=C3C(=O)C1=2
InChiKey:
UTSVPXMQSFGQTM-DCXZOGHSSA-N
InChi :
InChI=1S/C18H12O6/c1-21-11-7-12-13(8-5-6-22-18(8)24-12)17-15(11)16(20)14-9(19)3-2-4-10(14)23-17/h2-8,18-19H,1H3/t8-,18+/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Sterigmatocystine is a precursor of aflatoxins and a mycotoxin produced by common mold strains from Aspergillus versicolor. Sterigmatocystine, a inhibitor of G1 Phase and DNA synthesis, is used to inhibit p21 activity. Sterigmatocystine has teratogenic, and carcinogenic effects in animals.|Product information|CAS Number: 10048-13-2|Molecular Weight: 324.28|Formula: C18H12O6|Chemical Name: (3S, 7R)-15-hydroxy-11-methoxy-6, 8, 20-trioxapentacyclo[10.8.0.0, .0, .0, ]icosa-1(12), 2(9), 4, 10, 14(19), 15, 17-heptaen-13-one|Smiles: COC1=CC2O[C@H]3OC=C[C@H]3C=2C2OC3=CC=CC(O)=C3C(=O)C1=2|InChiKey: UTSVPXMQSFGQTM-DCXZOGHSSA-N|InChi: InChI=1S/C18H12O6/c1-21-11-7-12-13(8-5-6-22-18(8)24-12)17-15(11)16(20)14-9(19)3-2-4-10(14)23-17/h2-8,18-19H,1H3/t8-,18+/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Water-18O Activator |Shelf Life: ≥360 days if stored properly.Pancreatin Data Sheet |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:31608713 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Sterigmatocystine-induced DNA damage activates the ATM/53-dependent signaling pathway, which contributes to the induction of G2 arrest in GES-1 cells.|In Vivo:|Sterigmatocystine (ip; 3 mg/kg once daily for 14 days) inhibits p21WAF1/CIP1.|References:|Kusunoki M, et al. Long-term administration of the fungus toxin, sterigmatocystin, induces intestinal metaplasia and increases the proliferative activity of PCNA, p53, and MDM2 in the gastric mucosa of aged Mongolian gerbils. Environ Health Prev Med. 2011 Jul;16(4):224-31.Schroeder HW, et al. Production of sterigmatocystin by some species of the genus Aspergillus and its toxicity to chicken embryos. Appl Microbiol. 1975 Oct;30(4):589-91.Tong YF, et al. Cyclin-Dependent Kinase Inhibitor p21WAF1/CIP1 Facilitates the Development of CardiacHypertroph. Cell Physiol Biochem. 2017;42(4):1645-1656.Products are for research use only. Not for human use.|