Ter or compromise the delivery of scheduled radiation doses or the pharmacokinetics of chemotherapy [1]. They also concluded that adverse side effects, such as skin reactions, are tolerable, and adverse CP-868596 manufacturer pulmonary events are not statistically more frequent in patients receiving cetuximab [5,6]. However, several series revealed an increased risk of infection events, neutropenia, or pulmonary adverse reactions, in patients treated with cetuximab. In a meta-analysis, patients treated with 1655472 cetuximab incurred an 25033180 additional 12 risk for developing severe neutropenia [7]. A higher rate of high-grade infections was observed with the use of cetuximab in addition to chemotherapy in a randomized phase III study [8]. Increased dyspnea and respiratory insufficiency were noted in head and neck cancer patients undergoing cetuximab therapy [9]. Death due to pneumonia was observed in patients with locoregionally advanced head and neck cancer who were administered aInfection Risk in HNC with Cetuximab TherapyTable 1. Demographic characteristics for head and cancer patients by treatment modality (n = 1083).VariablesWith cetuximab (n = 158) n( )Without cetuximab (n = 925) n( )P-valueAge, yr Mean6SD Gender Male Female Charlson Comorbidity Index Score =0 1 Socioeconomic status High ( NT 20001 or US 626 ) Low ( NT 20000 or US 625 ) Urbanization level Urban/Suburban Rural Region of residence Northern/Central Southern/Eastern Treatment modality Surgery+Chemotherapy+Radiotherapy Chemotherapy/Chemotherapy+Radiotherapy 76(48) 82(52) 486(53) 439(47) 112(71) 46(29) 724(78) 201(22) 97(61) 61(39) 646(70) 279(30) 25(16) 133(84) 239(26) 686(74) 89(56) 69(44) 474(51) 451(49) 150(95) 8(5) 892(96) 33(4) 67613,0.0.0.0.0.0.0.concurrent cetuximab, cisplatin, and boost radiotherapy regimen that was not recommended outside of the clinical trial setting [10]. The purpose of this study was to examine the incidence of infection events in head and neck cancer patients identified through the National Health Insurance Research Database (NHIRD) in Taiwan. This allowed for a comparison of the risk of infection events between head and neck cancer patientsreceiving cetuximab therapy and those who were not treated with this compound. It also provided an opportunity to outline follow-up CPI-203 site suggestions for cetuximab-treated head and neck cancer patients. Propensity score analysis and instrumental variable analysis techniques were utilized to minimize the selection bias in observational medical studies, such as our NHIRD [11,12].Figure 1. Infectious complications in head and neck cancer patients. doi:10.1371/journal.pone.0050163.gInfection Risk in HNC with Cetuximab TherapyMaterials and Methods Ethics StatementThis study was initiated after approval by the Institutional Review Board of the Buddhist Dalin Tzu Chi General Hospital, Taiwan (IRB B10001018). Since all identifying personal information was stripped from the secondary files before analysis, the review board waived the requirement for written informed consent from the patients involved.than NT 20000 or US 625 per month), and 2) high SES (NT 20001 or US 626 per month or more) [15]. The urbanization level of residence is also associated with cancer outcomes and was therefore included in our analysis [16]. We recorded the level of urbanization as urban and sub-urban (urbanization level 1?) or rural (urbanization level 4?).Statistical AnalysisThe SAS (version 9.2; SAS Institute, Inc., Cary, NC, USA) and SPSS (version 15, SPSS Inc., Chicago,.Ter or compromise the delivery of scheduled radiation doses or the pharmacokinetics of chemotherapy [1]. They also concluded that adverse side effects, such as skin reactions, are tolerable, and adverse pulmonary events are not statistically more frequent in patients receiving cetuximab [5,6]. However, several series revealed an increased risk of infection events, neutropenia, or pulmonary adverse reactions, in patients treated with cetuximab. In a meta-analysis, patients treated with 1655472 cetuximab incurred an 25033180 additional 12 risk for developing severe neutropenia [7]. A higher rate of high-grade infections was observed with the use of cetuximab in addition to chemotherapy in a randomized phase III study [8]. Increased dyspnea and respiratory insufficiency were noted in head and neck cancer patients undergoing cetuximab therapy [9]. Death due to pneumonia was observed in patients with locoregionally advanced head and neck cancer who were administered aInfection Risk in HNC with Cetuximab TherapyTable 1. Demographic characteristics for head and cancer patients by treatment modality (n = 1083).VariablesWith cetuximab (n = 158) n( )Without cetuximab (n = 925) n( )P-valueAge, yr Mean6SD Gender Male Female Charlson Comorbidity Index Score =0 1 Socioeconomic status High ( NT 20001 or US 626 ) Low ( NT 20000 or US 625 ) Urbanization level Urban/Suburban Rural Region of residence Northern/Central Southern/Eastern Treatment modality Surgery+Chemotherapy+Radiotherapy Chemotherapy/Chemotherapy+Radiotherapy 76(48) 82(52) 486(53) 439(47) 112(71) 46(29) 724(78) 201(22) 97(61) 61(39) 646(70) 279(30) 25(16) 133(84) 239(26) 686(74) 89(56) 69(44) 474(51) 451(49) 150(95) 8(5) 892(96) 33(4) 67613,0.0.0.0.0.0.0.concurrent cetuximab, cisplatin, and boost radiotherapy regimen that was not recommended outside of the clinical trial setting [10]. The purpose of this study was to examine the incidence of infection events in head and neck cancer patients identified through the National Health Insurance Research Database (NHIRD) in Taiwan. This allowed for a comparison of the risk of infection events between head and neck cancer patientsreceiving cetuximab therapy and those who were not treated with this compound. It also provided an opportunity to outline follow-up suggestions for cetuximab-treated head and neck cancer patients. Propensity score analysis and instrumental variable analysis techniques were utilized to minimize the selection bias in observational medical studies, such as our NHIRD [11,12].Figure 1. Infectious complications in head and neck cancer patients. doi:10.1371/journal.pone.0050163.gInfection Risk in HNC with Cetuximab TherapyMaterials and Methods Ethics StatementThis study was initiated after approval by the Institutional Review Board of the Buddhist Dalin Tzu Chi General Hospital, Taiwan (IRB B10001018). Since all identifying personal information was stripped from the secondary files before analysis, the review board waived the requirement for written informed consent from the patients involved.than NT 20000 or US 625 per month), and 2) high SES (NT 20001 or US 626 per month or more) [15]. The urbanization level of residence is also associated with cancer outcomes and was therefore included in our analysis [16]. We recorded the level of urbanization as urban and sub-urban (urbanization level 1?) or rural (urbanization level 4?).Statistical AnalysisThe SAS (version 9.2; SAS Institute, Inc., Cary, NC, USA) and SPSS (version 15, SPSS Inc., Chicago,.