Journal.pone.0123479 April 7,7 /Rational Management of DiarrheaTable 3. Association of physician’s characteristics and knowledge regarding diarrhea with (-)-BlebbistatinMedChemExpress (S)-(-)-Blebbistatin Rationality of fluid management and laboratory testing practices while treating diarrhea cases (Na = 264). Practitioners’ characteristics and knowledge Categories Rationality of commonly regarding diarrhea (domain-wise and as a whole) administered IV fluid for the correction of severe dehydration ORb (95 CIc) Category of the TSA supplier practitioner (Reference = Non-qualified) Duration of practice (Reference: <10yrs) Attached to which type of healthcare facility? (Reference = None) General Specialist 10yrs Private sector 3.75(1.75?.02) 2.72(1.19?.24) 0.79(0.39?.54) 3.74(1.10?12.65) p values <0.001 0.018 0.472 0.034 0.016 0.193 0.017 0.457 0.004 0.243 0.163 0.003 0.037 0.295 0.127 0.940 0.029 0.452 <0.001 Rationality of commonly advised laboratory test for diagnosis of causative organism ORb (95 CIc) 3.30(1.67?.48) 3.95(1.95?.00) 1.52(0.80?.92) 1.81(0.80?.12) 6.59(1.90?22.88) 1.04(0.56?.92) 1.62(0.73?.58) 1.24(0.63?.41) 1.56(0.75?.26) 2.00(1.08?.70) 1.83(0.82?.08) 1.85(0.76?.49) 2.67(1.15?.22) 0.88(0.44?.78) 1.80(0.92?.50) 0.79(0.43?.47) 1.88(0.87?.03) 1.97(1.04?.72) 2.19(1.03?.64) p values <0.001 <0.001 0.204 0.156 0.003 0.896 0.232 0.536 0.233 0.028 0.138 0.175 0.023 0.722 0.086 0.458 0.107 0.037 0.041 Rationality of laboratory testing strategy for the diagnosis of causative organism ORb (95 CIc) 4.36(2.02?.41) 5.02(2.27?11.11) 1.59(0.77?.29) 2.92(0.99?.58) 11.25(2.73?46.35) 1.56(0.78?.13) 2.05(0.85?.96) 1.36(0.63?.94) 2.23(0.99?.01) 2.28(1.14?.57) 2.29(0.96?.49) 1.47(0.57?.81) 2.14(0.87?.26) 0.89(0.40?.98) 2.34(1.15?.75) 0.94(0.48?.86) 2.03(0.89?.60) 2.36(1.15?.84) 2.68(1.17?.15) p values <0.001 <0.001 0.212 0.052 <0.001 0.211 0.110 0.433 0.052 0.021 0.063 0.428 0.097 0.773 0.019 0.861 0.091 0.020 0.Govt. sector 6.97(1.44?33.68) Knowledge of the participating physicians regarding Signs symptoms of diarrheal diseases (Reference = Worst) Occurrence and spread of diarrhea (Reference = Worst) Management of diarrhea (Reference = Worst) Prevention and control of diarrhea (Reference = Worst) Better Best Better Best Better Best Better Best Cholera as a whole (Reference = Worst) Oral rehydration solution and its use (Reference = Worst) Diarrhea as a whole (Reference = Worst) Better Best Better Best Better Best 1.65(0.78?.51) 3.00(1.22?.41) 1.39(0.59?.29) 3.57(1.51?.47) 1.53(0.75?.12) 1.88(0.78?.53) 9.89(2.24?43.62) 4.89(1.10?21.83) 1.51(0.70?.23) 1.83(0.84?.97) 1.03(0.50?.12) 2.55(1.10?.91) 1.36(0.61?.01) 4.57(2.03?10.27)a b cN = Total number of participating physicians. OR = Odds ratio. 95 CI = 95 Confidence Interval.doi:10.1371/journal.pone.0123479.tprevention/control (OR = 4.89,p = 0.037) and ORS (OR = 2.55,p = 0.029). Better knowledge (reference = worst) regarding management (for better knowledge: OR = 2.00,p = 0.028) and prevention/control (for best knowledge: OR = 2.67,p = 0.023) were associated with higher odds of rationality in laboratory testing advice while better knowledge (reference = worst) about cholera (for best knowledge: OR = 2.34,p = 0.019) and management of diarrhea (for better knowledge: OR = 2.28,p = 0.021) were associated with increased likelihood of rational laboratory testing strategy. (Table 3) Practitioners having better (reference = worst) overall knowledge regarding diarrhea, had higher odds of rationality while prescribing antibiotics to patients suffering from acute wat.Journal.pone.0123479 April 7,7 /Rational Management of DiarrheaTable 3. Association of physician's characteristics and knowledge regarding diarrhea with rationality of fluid management and laboratory testing practices while treating diarrhea cases (Na = 264). Practitioners' characteristics and knowledge Categories Rationality of commonly regarding diarrhea (domain-wise and as a whole) administered IV fluid for the correction of severe dehydration ORb (95 CIc) Category of the practitioner (Reference = Non-qualified) Duration of practice (Reference: <10yrs) Attached to which type of healthcare facility? (Reference = None) General Specialist 10yrs Private sector 3.75(1.75?.02) 2.72(1.19?.24) 0.79(0.39?.54) 3.74(1.10?12.65) p values <0.001 0.018 0.472 0.034 0.016 0.193 0.017 0.457 0.004 0.243 0.163 0.003 0.037 0.295 0.127 0.940 0.029 0.452 <0.001 Rationality of commonly advised laboratory test for diagnosis of causative organism ORb (95 CIc) 3.30(1.67?.48) 3.95(1.95?.00) 1.52(0.80?.92) 1.81(0.80?.12) 6.59(1.90?22.88) 1.04(0.56?.92) 1.62(0.73?.58) 1.24(0.63?.41) 1.56(0.75?.26) 2.00(1.08?.70) 1.83(0.82?.08) 1.85(0.76?.49) 2.67(1.15?.22) 0.88(0.44?.78) 1.80(0.92?.50) 0.79(0.43?.47) 1.88(0.87?.03) 1.97(1.04?.72) 2.19(1.03?.64) p values <0.001 <0.001 0.204 0.156 0.003 0.896 0.232 0.536 0.233 0.028 0.138 0.175 0.023 0.722 0.086 0.458 0.107 0.037 0.041 Rationality of laboratory testing strategy for the diagnosis of causative organism ORb (95 CIc) 4.36(2.02?.41) 5.02(2.27?11.11) 1.59(0.77?.29) 2.92(0.99?.58) 11.25(2.73?46.35) 1.56(0.78?.13) 2.05(0.85?.96) 1.36(0.63?.94) 2.23(0.99?.01) 2.28(1.14?.57) 2.29(0.96?.49) 1.47(0.57?.81) 2.14(0.87?.26) 0.89(0.40?.98) 2.34(1.15?.75) 0.94(0.48?.86) 2.03(0.89?.60) 2.36(1.15?.84) 2.68(1.17?.15) p values <0.001 <0.001 0.212 0.052 <0.001 0.211 0.110 0.433 0.052 0.021 0.063 0.428 0.097 0.773 0.019 0.861 0.091 0.020 0.Govt. sector 6.97(1.44?33.68) Knowledge of the participating physicians regarding Signs symptoms of diarrheal diseases (Reference = Worst) Occurrence and spread of diarrhea (Reference = Worst) Management of diarrhea (Reference = Worst) Prevention and control of diarrhea (Reference = Worst) Better Best Better Best Better Best Better Best Cholera as a whole (Reference = Worst) Oral rehydration solution and its use (Reference = Worst) Diarrhea as a whole (Reference = Worst) Better Best Better Best Better Best 1.65(0.78?.51) 3.00(1.22?.41) 1.39(0.59?.29) 3.57(1.51?.47) 1.53(0.75?.12) 1.88(0.78?.53) 9.89(2.24?43.62) 4.89(1.10?21.83) 1.51(0.70?.23) 1.83(0.84?.97) 1.03(0.50?.12) 2.55(1.10?.91) 1.36(0.61?.01) 4.57(2.03?10.27)a b cN = Total number of participating physicians. OR = Odds ratio. 95 CI = 95 Confidence Interval.doi:10.1371/journal.pone.0123479.tprevention/control (OR = 4.89,p = 0.037) and ORS (OR = 2.55,p = 0.029). Better knowledge (reference = worst) regarding management (for better knowledge: OR = 2.00,p = 0.028) and prevention/control (for best knowledge: OR = 2.67,p = 0.023) were associated with higher odds of rationality in laboratory testing advice while better knowledge (reference = worst) about cholera (for best knowledge: OR = 2.34,p = 0.019) and management of diarrhea (for better knowledge: OR = 2.28,p = 0.021) were associated with increased likelihood of rational laboratory testing strategy. (Table 3) Practitioners having better (reference = worst) overall knowledge regarding diarrhea, had higher odds of rationality while prescribing antibiotics to patients suffering from acute wat.