Sting TC, PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/28878015 LDL-C, 12 study of HIV-infected patients HDL-C, TGL, and receiving either a on bPI or EFV, TC:HDL-C ratio. and statin treatment. Four weeks after statin interruption, bPI or EFV was switched to ETR (400 mg for 8 weeks) if serum low-density lipoprotein cholesterol (LDL-C) was 3 mM. The primary endpoint was the proportion of patients not qualifying for statin treatment 8 weeks after the ETR switch.[137]Maggi et al. BMC Infectious Diseases (2017) 17:Page 7 ofthe lipid profile, purchase Nutlin-3a chiral increase from baseline in fasting total cholesterol, LDL cholesterol, HDL and triglycerides were observed in TAF than with TDF. TAF has no “statin-like” phenomenon which characterized TDF. Long-term data are not know.Pharmacological treatment of dyslipidemiaDrugs for the treatment of hypercholesterolemia StatinsCabotegravirCabotegravir is an investigational HIV INI drug, currently being studied in Phase IIb clinical trials. During preliminary studies conducted on healthy subjects both in monotherapy and in combination with RPV [39, 40] no consistent, clinically significant, or dose-related changes in haematology, clinical chemistry, vital signs, or ECG abnormalities or trends were observed. Lou et al. [41], in a study that assessed its effect on cardiac repolarization in healthy subjects, demonstrated PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/26080418 that cabotegravir at a supratherapeutic dose had no effect on cardiac repolarization. In a fase IIa study, Spreen et al. [42] described two cases of laboratory abnormalities in HIV-1 infected patients in Cabotegravir monotherapy arm. A subject with type I diabetes had grade 2 hyperglycemia at baseline and at all time points other than day 7 (hypoglycemia) and the follow-up visit (grade 3 hyperglycemia). The other subject, on day 7, had grade 4 TGL elevation subsequent to a very high at meal the previous evening, and TGL were within normal limits at all other readings. Even the phase IIb studies, LATTE and LATTE-2 (still ongoing), underlined the good safety profile of cabotegravir with no cases of ECG abnormalities or metabolic disorders [43].DoravirineDoravirine is a NNRTI currently being studied in Phase III clinical trials as both a single-drug tablet and as part of a fixed-dose combination tablet. In a preliminary study with single and multiple doses of doravirine in healthy subjects, no serious adverse events were reported, and there were no consistent, clinically relevant, treatment-related effects of doravirine on vital signs or ECGs. Overall, no clinically significant trends or signals were observed in laboratory assessments, vital signs or ECGs [44]. In a randomized, double-blind, placebocontrolled, short-term monotherapy study of doravirine Shurmann et al. described no clinically significant abnormalities in vital signs, routine blood and urine chemistry panels, haematology, ECGs, or physical or neurological examinations in any participant [45]. Results of a phase IIb clinical trial, presented by Gatell et al. at the 12th International Congress on HIV Drug Therapy being held in Glasgow, showed that 6.8 of patients had an increase in total cholesterol and 6.3 an increase of LDL cholesterol [46].Statins are the cornerstone of the treatment of hypercholesterolemia. They reduce the synthesis of cholesterol in the liver by competitively inhibiting the hydroxy-3methylglutaryl coenzyme A (HMG-CoA) reductase activity. The reduction in intracellular cholesterol concentrations induces LDL receptor expression on the hepatocyte cell surface, which results in in.