Athologic evaluation is a useful procedure to confirm a clinically suspected
Athologic evaluation is a useful procedure to confirm a clinically suspected diagnosis of Sweet’s syndrome. Pathologic features of Sweet’s syndrome, such as the diffuse inflammatory infiltrate of neutrophils in the dermis, subcutaneous fat, or both can also be observed in cutaneous lesions caused by an infectious agent. Therefore, it may also be prudent to also submit lesional tissue for bacterial, fungal, mycobacterial, and possibly viral cultures [1,2]. Laboratory evaluation The most consistent laboratory PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/28380356 abnormalties in patients with Sweet’s syndrome are peripheral leukocytosis with neutrophilia and an elevated erythrocyte sedimentation rate [23]. However, an elevated white blood cell count is not always observed in all patients with biopsy-confirmed Sweet’s syndrome [26]. For example, some of the patients with malignancy-associated Sweet’s syndrome may have either anemia, neutropenia, and/or abnormal platelet counts.Extracutaneous manifestations of Sweet’s syndrome may result in other laboratory abnormalities. Abnormalites may be found on brain SPECTs, computerized axial tomography, electroencephalograms, magnetic resonance imaging and cerebrospinal fluid analysis in patients with central nervous system involvement. Urinalysis abnormalities (hematuria and proteinuria) may be observed in patients with dermatosis-related kidney involvement. Hepatic serum enzyme elevation may be present in patients with Sweet’s syndrome-associated liver involvment. Pleural effusions and corticosteroid-responsive culture-negative infiltrates may be present on chest roentgenograms in patients with Sweet’s syndrome whoPage 14 of(page number not for citation purposes)Orphanet Journal of Rare Diseases 2007, 2:http://www.OJRD.com/content/2/1/Table 8: Clinical differential diagnosis of Sweet’s syndromeCutaneous conditionsInfectious and inflammatory disordersNeoplastic conditionsReactive erythemasSystemic diseasesVasculitisAcral erythema Drug eruptions Halogenoderma Rosacea fulminans Bacterial sepsis Cellulitis Erysipelas Herpes simplex virus Herpes zoster virus Leprosy Lymphangiitis Panniculitis Pyoderma gangrenosum Syphilis Systemic mycoses Thrombophlebitis Tuberculosis Viral exanthem Chloroma Leukemia cutis Lymphoma Metastatic tumor Erythema multiforme Erythema nodosum Urticaria Behcet’s disease Bowel bypass syndrome Dermatomyositis Familial Mediterranean fever Lupus erythematosus Erythema elevatum diutinum Granuloma faciale Leukocytoclastic vasculitis Periarteritis nodosaneoplasms that had concurrently or subsequently been discovered in previously cancer-free Sweet’s syndrome patients and the age-related recommendations by the American Cancer Society for the early detection of cancer in asymptomatic persons [406]. They recommended: (1) a detailed medical history; (2) a complete physical examination, including: (a) examination of the SF 1101 web thyroid, lymph nodes, oral cavity, and skin; (b) digital rectal examination; (c) breast, ovary, and pelvic examination in women; and (d) prostate and testicle examination in men; (3) laboratory evaluation: (a) carcinoembryonic antigen level; (b) complete blood cell count with leukocyte differential and platelet count; (c) pap test in women; (c) serum chemistries; (d) stool guaiac slide test; (e) urinalysis; and (f) urine culture; and (4) other screening tests: (a) chest roentgenograms; (b) endometrial tissue sampling in either menopausal women or women with a history of abnormal uterine bleeding, estrogen therapy, failure to ov.